DegronMD - Q9P0L9(PKD2L1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A24T	TCGA-13-0884	OV	TCGA	DNPAYSGPP	CBL_PTK	21:29	Mutation altering degron motif	0.6028
p.A24T	DO28913	OV	ICGC	DNPAYSGPP	CBL_PTK	21:29	Mutation altering degron motif	0.6028
p.K14N	TCGA-80-5607	LUAD	TCGA	DNPAYSGPP	CBL_PTK	21:29	Mutation substituting flanking lysine	0.25
p.K14N	DO25957	LUAD	ICGC	DNPAYSGPP	CBL_PTK	21:29	Mutation substituting flanking lysine	0.25
p.R36K	TCGA-FU-A770	CESC	TCGA	DNPAYSGPP	CBL_PTK	21:29	Mutation rewiring degron network	0.1389
p.R36K	DO49972	CESC	ICGC	DNPAYSGPP	CBL_PTK	21:29	Mutation rewiring degron network	0.1389
p.G33R	TCGA-FW-A3R5	SKCM	TCGA	DNPAYSGPP	CBL_PTK	21:29	Mutation rewiring degron network	0.2222
p.G33R	DO37406	SKCM	ICGC	DNPAYSGPP	CBL_PTK	21:29	Mutation rewiring degron network	0.2222
p.S30F	TCGA-G2-A2EO	BLCA	TCGA	DNPAYSGPP	CBL_PTK	21:29	Mutation rewiring degron network	0.3056
p.S30F	DO456	BLCA	ICGC	DNPAYSGPP	CBL_PTK	21:29	Mutation rewiring degron network	0.3056
p.S30F	SIDM00993	Plasma Cell Myeloma	GDSC	DNPAYSGPP	CBL_PTK	21:29	Mutation rewiring degron network	0.3056
p.S30F	ACH-000838	Myeloma	CCLE	DNPAYSGPP	CBL_PTK	21:29	Mutation rewiring degron network	0.3056
p.S30F	AMO-1	haematopoietic and lymphoid tissue	COSMIC	DNPAYSGPP	CBL_PTK	21:29	Mutation rewiring degron network	0.3056
p.G27V	DO225244	BRCA	ICGC	DNPAYSGPP	CBL_PTK	21:29	Mutation altering degron motif	0.6421
p.G27V	SIDM00779	Colorectal Carcinoma	GDSC	DNPAYSGPP	CBL_PTK	21:29	Mutation altering degron motif	0.6421
p.G27V	ACH-000491	Colon/Colorectal Cancer	CCLE	DNPAYSGPP	CBL_PTK	21:29	Mutation altering degron motif	0.6421
p.G27V	NCI-H716	large intestine	COSMIC	DNPAYSGPP	CBL_PTK	21:29	Mutation altering degron motif	0.6421
p.P23T	DO229018	LICA	ICGC	DNPAYSGPP	CBL_PTK	21:29	Mutation altering degron motif	0.5919
p.H32Y	DO228897	LICA	ICGC	DNPAYSGPP	CBL_PTK	21:29	Mutation rewiring degron network	0.25
p.D21N	DO220882	MELA	ICGC	DNPAYSGPP	CBL_PTK	21:29	Mutation altering degron motif	0.5821
p.E11K	DO222702	MELA	ICGC	DNPAYSGPP	CBL_PTK	21:29	Mutation rewiring degron network	0.0556
p.A19S	SIDM00485	Oral Cavity Carcinoma	GDSC	DNPAYSGPP	CBL_PTK	21:29	Mutation rewiring degron network	0.2778
p.A19S	ACH-000794	Head and Neck Cancer	CCLE	DNPAYSGPP	CBL_PTK	21:29	Mutation rewiring degron network	0.2778
p.A19S	BICR22	upper aerodigestive tract	COSMIC	DNPAYSGPP	CBL_PTK	21:29	Mutation rewiring degron network	0.2778

Kaplan plot for PKD2L1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PKD2L1

UniProt ID: Q9P0L9

Entrez ID: 9033

Protein name: Polycystic kidney disease 2-like 1 protein (Polycystin-2 homolog) (Polycystin-2L1) (Polycystin-L) (Polycystin-L1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PKD2L1 in