DegronMD

Uniprot ID: Q9P0L9

Source protein: Polycystic kidney disease 2-like 1 protein

Source gene: PKD2L1

Class: CBL_PTK

Location: 21:29

E3 ligase: CBL

DEGRON score: 0.9991

ASA_SCORE: 77.6889

COIL: 0.9478

CONS_SCORE: 0.4493

DSS_SCORE: 0.6078

HELIX: 0.0213

FCONS_SCORE: 1.0688

RIG_SCORE: 0.5904

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A24T	TCGA-13-0884	OV	TCGA	DNPAYSGPP	CBL_PTK	0.6028
p.A24T	DO28913	OV	ICGC	DNPAYSGPP	CBL_PTK	0.6028
p.K14N	TCGA-80-5607	LUAD	TCGA	DNPAYSGPP	CBL_PTK	0.25
p.K14N	DO25957	LUAD	ICGC	DNPAYSGPP	CBL_PTK	0.25
p.R36K	TCGA-FU-A770	CESC	TCGA	DNPAYSGPP	CBL_PTK	0.1389
p.R36K	DO49972	CESC	ICGC	DNPAYSGPP	CBL_PTK	0.1389
p.G33R	TCGA-FW-A3R5	SKCM	TCGA	DNPAYSGPP	CBL_PTK	0.2222
p.G33R	DO37406	SKCM	ICGC	DNPAYSGPP	CBL_PTK	0.2222
p.S30F	TCGA-G2-A2EO	BLCA	TCGA	DNPAYSGPP	CBL_PTK	0.3056
p.S30F	DO456	BLCA	ICGC	DNPAYSGPP	CBL_PTK	0.3056
p.S30F	SIDM00993	Plasma Cell Myeloma	GDSC	DNPAYSGPP	CBL_PTK	0.3056
p.S30F	ACH-000838	Myeloma	CCLE	DNPAYSGPP	CBL_PTK	0.3056
p.S30F	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	DNPAYSGPP	CBL_PTK	0.3056
p.G27V	DO225244	BRCA	ICGC	DNPAYSGPP	CBL_PTK	0.6421
p.G27V	SIDM00779	Colorectal Carcinoma	GDSC	DNPAYSGPP	CBL_PTK	0.6421
p.G27V	ACH-000491	Colon/Colorectal Cancer	CCLE	DNPAYSGPP	CBL_PTK	0.6421
p.G27V	NCI-H716	large_intestine	COSMIC	DNPAYSGPP	CBL_PTK	0.6421
p.P23T	DO229018	LICA	ICGC	DNPAYSGPP	CBL_PTK	0.5919
p.H32Y	DO228897	LICA	ICGC	DNPAYSGPP	CBL_PTK	0.25
p.D21N	DO220882	MELA	ICGC	DNPAYSGPP	CBL_PTK	0.5821
p.E11K	DO222702	MELA	ICGC	DNPAYSGPP	CBL_PTK	0.0556
p.A19S	SIDM00485	Oral Cavity Carcinoma	GDSC	DNPAYSGPP	CBL_PTK	0.2778
p.A19S	ACH-000794	Head and Neck Cancer	CCLE	DNPAYSGPP	CBL_PTK	0.2778
p.A19S	BICR22	upper_aerodigestive_tract	COSMIC	DNPAYSGPP	CBL_PTK	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P0L9	Polycystic kidney disease 2-like 1 protein	CBL_PTK	21:29	DNPAYSGPP	CBL	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons