DegronMD - Q9P0U4(CXXC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R236S	TCGA-CR-7389	HNSC	TCGA	PVTPSES	DEG_SCF_FBW7_1	225:231	Mutation rewiring degron network	0.1944
p.R236S	DO14190	HNSC	ICGC	PVTPSES	DEG_SCF_FBW7_1	225:231	Mutation rewiring degron network	0.1944
p.P235L	TCGA-IE-A3OV	SARC	TCGA	PVTPSES	DEG_SCF_FBW7_1	225:231	Mutation rewiring degron network	0.2222
p.P235L	DO220149	SARC	ICGC	PVTPSES	DEG_SCF_FBW7_1	225:231	Mutation rewiring degron network	0.2222
p.S222L	TCGA-K4-A54R	BLCA	TCGA	PVTPSES	DEG_SCF_FBW7_1	225:231	Mutation blocking phosphorylation signal	0.6944
p.S222L	DO48611	BLCA	ICGC	PVTPSES	DEG_SCF_FBW7_1	225:231	Mutation blocking phosphorylation signal	0.6944
p.R236H	DO222427	BTCA	ICGC	PVTPSES	DEG_SCF_FBW7_1	225:231	Mutation rewiring degron network	0.1944
p.T227M	DO52453	COCA	ICGC	PVTPSES	DEG_SCF_FBW7_1	225:231	Mutation altering degron motif	0.8534
p.T227M	DO229013	COCA	ICGC	PVTPSES	DEG_SCF_FBW7_1	225:231	Mutation altering degron motif	0.8534
p.T227M	DO229005	COCA	ICGC	PVTPSES	DEG_SCF_FBW7_1	225:231	Mutation altering degron motif	0.8534
p.T227M	DO231209	LUSC	ICGC	PVTPSES	DEG_SCF_FBW7_1	225:231	Mutation altering degron motif	0.8534
p.T227M	SIDM00338	Acute Myeloid Leukemia	GDSC	PVTPSES	DEG_SCF_FBW7_1	225:231	Mutation altering degron motif	0.8534
p.T227M	SIDM01145	Gastric Carcinoma	GDSC	PVTPSES	DEG_SCF_FBW7_1	225:231	Mutation altering degron motif	0.8534
p.T227M	SIDM00251	Gastric Carcinoma	GDSC	PVTPSES	DEG_SCF_FBW7_1	225:231	Mutation altering degron motif	0.8534
p.T227M	SIDM01061	Oral Cavity Carcinoma	GDSC	PVTPSES	DEG_SCF_FBW7_1	225:231	Mutation altering degron motif	0.8534
p.T227M	SIDM01336	Glioblastoma	GDSC	PVTPSES	DEG_SCF_FBW7_1	225:231	Mutation altering degron motif	0.8534
p.T227M	SIDM01394	Kidney Carcinoma	GDSC	PVTPSES	DEG_SCF_FBW7_1	225:231	Mutation altering degron motif	0.8534
p.P238S	DO229062	LICA	ICGC	PVTPSES	DEG_SCF_FBW7_1	225:231	Mutation rewiring degron network	0.1389
p.R237Q	DO218900	SKCA	ICGC	PVTPSES	DEG_SCF_FBW7_1	225:231	Mutation rewiring degron network	0.1667

Kaplan plot for CXXC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CXXC1

UniProt ID: Q9P0U4

Entrez ID: 30827

Protein name: CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CXXC1 in