DegronMD

Uniprot ID: Q9P0U4

Source protein: CXXC-type zinc finger protein 1

Source gene: CXXC1

Class: DEG_SCF_FBW7_1

Location: 225:231

E3 ligase: FBXW7

DEGRON score: 0.9468

ASA_SCORE: 96.4571

COIL: 0.936

CONS_SCORE: 0.3532

DSS_SCORE: 0.6602

HELIX: 0.045

FCONS_SCORE: 0.9548

RIG_SCORE: 0.5796

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R236S	TCGA-CR-7389	HNSC	TCGA	PVTPSES	DEG_SCF_FBW7_1	0.1944
p.R236S	DO14190	HNSC	ICGC	PVTPSES	DEG_SCF_FBW7_1	0.1944
p.P235L	TCGA-IE-A3OV	SARC	TCGA	PVTPSES	DEG_SCF_FBW7_1	0.2222
p.P235L	DO220149	SARC	ICGC	PVTPSES	DEG_SCF_FBW7_1	0.2222
p.S222L	TCGA-K4-A54R	BLCA	TCGA	PVTPSES	DEG_SCF_FBW7_1	0.6944
p.S222L	DO48611	BLCA	ICGC	PVTPSES	DEG_SCF_FBW7_1	0.6944
p.R236H	DO222427	BTCA	ICGC	PVTPSES	DEG_SCF_FBW7_1	0.1944
p.T227M	DO52453	COCA	ICGC	PVTPSES	DEG_SCF_FBW7_1	0.8534
p.T227M	DO229013	COCA	ICGC	PVTPSES	DEG_SCF_FBW7_1	0.8534
p.T227M	DO229005	COCA	ICGC	PVTPSES	DEG_SCF_FBW7_1	0.8534
p.T227M	DO231209	LUSC	ICGC	PVTPSES	DEG_SCF_FBW7_1	0.8534
p.T227M	SIDM00338	Acute Myeloid Leukemia	GDSC	PVTPSES	DEG_SCF_FBW7_1	0.8534
p.T227M	SIDM01145	Gastric Carcinoma	GDSC	PVTPSES	DEG_SCF_FBW7_1	0.8534
p.T227M	SIDM00251	Gastric Carcinoma	GDSC	PVTPSES	DEG_SCF_FBW7_1	0.8534
p.T227M	SIDM01061	Oral Cavity Carcinoma	GDSC	PVTPSES	DEG_SCF_FBW7_1	0.8534
p.T227M	SIDM01336	Glioblastoma	GDSC	PVTPSES	DEG_SCF_FBW7_1	0.8534
p.T227M	SIDM01394	Kidney Carcinoma	GDSC	PVTPSES	DEG_SCF_FBW7_1	0.8534
p.P238S	DO229062	LICA	ICGC	PVTPSES	DEG_SCF_FBW7_1	0.1389
p.R237Q	DO218900	SKCA	ICGC	PVTPSES	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P0U4	CXXC-type zinc finger protein 1	DEG_SCF_FBW7_1	225:231	PVTPSES	FBXW7	0.9468	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons