DegronMD - Q9P121(NTM)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F283C	TCGA-06-5416	GBM	TCGA	NRPFLSKLI	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.2778
p.F283C	DO10880	GBM	ICGC	NRPFLSKLI	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.2778
p.G268W	TCGA-38-4625	LUAD	TCGA	NRPFLSKLI	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.1944
p.G268W	DO23952	LUAD	ICGC	NRPFLSKLI	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.1944
p.G291V	TCGA-B0-4698	KIRC	TCGA	NRPFLSKLI	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.G291V	DO20368	KIRC	ICGC	NRPFLSKLI	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.0556
p.K266N	TCGA-B5-A1MR	UCEC	TCGA	NRPFLSKLI	DEG_APCC_DBOX_1	273:281	Mutation substituting flanking lysine	0.25
p.K266N	DO41758	UCEC	ICGC	NRPFLSKLI	DEG_APCC_DBOX_1	273:281	Mutation substituting flanking lysine	0.25
p.K266R	TCGA-D5-6920	COAD	TCGA	NRPFLSKLI	DEG_APCC_DBOX_1	273:281	Mutation substituting flanking lysine	0.25
p.K266R	DO8127	COAD	ICGC	NRPFLSKLI	DEG_APCC_DBOX_1	273:281	Mutation substituting flanking lysine	0.25
p.D289Y	TCGA-O2-A52Q	LUSC	TCGA	NRPFLSKLI	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.1111
p.D289Y	DO219219	LUSC	ICGC	NRPFLSKLI	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.1111
p.V269E	DO233214	GACA	ICGC	NRPFLSKLI	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.2222
p.N284D	DO233641	GACA	ICGC	NRPFLSKLI	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.25
p.V271M	DO233782	GACA	ICGC	NRPFLSKLI	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.2778
p.E272K	DO220877	MELA	ICGC	NRPFLSKLI	DEG_APCC_DBOX_1	273:281	Mutation rewiring degron network	0.3056

Kaplan plot for NTM in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NTM

UniProt ID: Q9P121

Entrez ID: 50863

Protein name: Neurotrimin (hNT) (IgLON family member 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NTM in