DegronMD

Uniprot ID: Q9P121

Source protein: Neurotrimin

Source gene: NTM

Class: DEG_APCC_DBOX_1

Location: 273:281

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5246

ASA_SCORE: 59.9111

COIL: 0.2908

CONS_SCORE: 0.5973

DSS_SCORE: 0.0905

HELIX: 0.0068

FCONS_SCORE: 0.8774

RIG_SCORE: 0.8856

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F283C	TCGA-06-5416	GBM	TCGA	NRPFLSKLI	DEG_APCC_DBOX_1	0.2778
p.F283C	DO10880	GBM	ICGC	NRPFLSKLI	DEG_APCC_DBOX_1	0.2778
p.G268W	TCGA-38-4625	LUAD	TCGA	NRPFLSKLI	DEG_APCC_DBOX_1	0.1944
p.G268W	DO23952	LUAD	ICGC	NRPFLSKLI	DEG_APCC_DBOX_1	0.1944
p.G291V	TCGA-B0-4698	KIRC	TCGA	NRPFLSKLI	DEG_APCC_DBOX_1	0.0556
p.G291V	DO20368	KIRC	ICGC	NRPFLSKLI	DEG_APCC_DBOX_1	0.0556
p.K266N	TCGA-B5-A1MR	UCEC	TCGA	NRPFLSKLI	DEG_APCC_DBOX_1	0.25
p.K266N	DO41758	UCEC	ICGC	NRPFLSKLI	DEG_APCC_DBOX_1	0.25
p.K266R	TCGA-D5-6920	COAD	TCGA	NRPFLSKLI	DEG_APCC_DBOX_1	0.25
p.K266R	DO8127	COAD	ICGC	NRPFLSKLI	DEG_APCC_DBOX_1	0.25
p.D289Y	TCGA-O2-A52Q	LUSC	TCGA	NRPFLSKLI	DEG_APCC_DBOX_1	0.1111
p.D289Y	DO219219	LUSC	ICGC	NRPFLSKLI	DEG_APCC_DBOX_1	0.1111
p.V269E	DO233214	GACA	ICGC	NRPFLSKLI	DEG_APCC_DBOX_1	0.2222
p.N284D	DO233641	GACA	ICGC	NRPFLSKLI	DEG_APCC_DBOX_1	0.25
p.V271M	DO233782	GACA	ICGC	NRPFLSKLI	DEG_APCC_DBOX_1	0.2778
p.E272K	DO220877	MELA	ICGC	NRPFLSKLI	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P121	Neurotrimin	DEG_APCC_DBOX_1	273:281	NRPFLSKLI	APC,CDC20,FZR1	0.5246	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons