DegronMD - Q9P1Q0(VPS54)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A160T	DO7828	COAD	ICGC	SRTDLEQVP	DEG_APCC_DBOX_1	155:163	Mutation altering degron motif	0.7139
p.L161H	DO7801	COAD	ICGC	SRTDLEQVP	DEG_APCC_DBOX_1	155:163	Mutation altering degron motif	0.7313
p.K172N	DO234337	ESAD	ICGC	SRTDLEQVP	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.0833
p.T166I	DO220013	SARC	ICGC	SRTDLEQVP	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.25
p.T151I	SIDM00845	Burkitt's Lymphoma	GDSC	SRTDLEQVP	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.2222
p.E145D	SIDM00845	Burkitt's Lymphoma	GDSC	SRTDLEQVP	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.0556
p.M167L	SIDM01002	Breast Carcinoma	GDSC	SRTDLEQVP	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.2222
p.M167L	EFM-192A	breast	COSMIC	SRTDLEQVP	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.2222
p.T147I	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRTDLEQVP	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1111
p.T147I	SIDM00299	Other Sarcomas	GDSC	SRTDLEQVP	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1111
p.T147I	SIDM00365	Small Cell Lung Carcinoma	GDSC	SRTDLEQVP	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1111
p.T147I	SIDM00397	Acute Myeloid Leukemia	GDSC	SRTDLEQVP	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1111
p.T147I	SIDM00616	Hepatocellular Carcinoma	GDSC	SRTDLEQVP	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1111
p.T147I	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRTDLEQVP	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1111
p.T147I	SIDM01622	Breast Carcinoma	GDSC	SRTDLEQVP	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1111
p.T147I	SIDM00500	Colorectal Carcinoma	GDSC	SRTDLEQVP	DEG_APCC_DBOX_1	155:163	Mutation rewiring degron network	0.1111
p.H155Q	ACH-000786	Lymphoma	CCLE	SRTDLEQVP	DEG_APCC_DBOX_1	155:163	Mutation altering degron motif	0.7582
p.H155Q	Daudi	haematopoietic and lymphoid tissue	COSMIC	SRTDLEQVP	DEG_APCC_DBOX_1	155:163	Mutation altering degron motif	0.7582
p.H155Q	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	SRTDLEQVP	DEG_APCC_DBOX_1	155:163	Mutation altering degron motif	0.7582
p.M155L	EFM-192A	breast	COSMIC	SRTDLEQVP	DEG_APCC_DBOX_1	155:163	Mutation altering degron motif	0.711

Kaplan plot for VPS54 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VPS54

UniProt ID: Q9P1Q0

Entrez ID: 51542

Protein name: Vacuolar protein sorting-associated protein 54 (Hepatocellular carcinoma protein 8) (Tumor antigen HOM-HCC-8) (Tumor antigen SLP-8p)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VPS54 in