DegronMD

Uniprot ID: Q9P1Q0

Source protein: Vacuolar protein sorting-associated protein 54

Source gene: VPS54

Class: DEG_APCC_DBOX_1

Location: 155:163

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9432

ASA_SCORE: 81.4111

COIL: 0.7339

CONS_SCORE: 0.3708

DSS_SCORE: 0.3613

HELIX: 0.2027

FCONS_SCORE: 1.0879

RIG_SCORE: 0.7781

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A160T	DO7828	COAD	ICGC	SRTDLEQVP	DEG_APCC_DBOX_1	0.7139
p.L161H	DO7801	COAD	ICGC	SRTDLEQVP	DEG_APCC_DBOX_1	0.7313
p.K172N	DO234337	ESAD	ICGC	SRTDLEQVP	DEG_APCC_DBOX_1	0.0833
p.T166I	DO220013	SARC	ICGC	SRTDLEQVP	DEG_APCC_DBOX_1	0.25
p.T151I	SIDM00845	Burkitt's Lymphoma	GDSC	SRTDLEQVP	DEG_APCC_DBOX_1	0.2222
p.E145D	SIDM00845	Burkitt's Lymphoma	GDSC	SRTDLEQVP	DEG_APCC_DBOX_1	0.0556
p.M167L	SIDM01002	Breast Carcinoma	GDSC	SRTDLEQVP	DEG_APCC_DBOX_1	0.2222
p.M167L	EFM-192A	breast	COSMIC	SRTDLEQVP	DEG_APCC_DBOX_1	0.2222
p.T147I	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRTDLEQVP	DEG_APCC_DBOX_1	0.1111
p.T147I	SIDM00299	Other Sarcomas	GDSC	SRTDLEQVP	DEG_APCC_DBOX_1	0.1111
p.T147I	SIDM00365	Small Cell Lung Carcinoma	GDSC	SRTDLEQVP	DEG_APCC_DBOX_1	0.1111
p.T147I	SIDM00397	Acute Myeloid Leukemia	GDSC	SRTDLEQVP	DEG_APCC_DBOX_1	0.1111
p.T147I	SIDM00616	Hepatocellular Carcinoma	GDSC	SRTDLEQVP	DEG_APCC_DBOX_1	0.1111
p.T147I	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRTDLEQVP	DEG_APCC_DBOX_1	0.1111
p.T147I	SIDM01622	Breast Carcinoma	GDSC	SRTDLEQVP	DEG_APCC_DBOX_1	0.1111
p.T147I	SIDM00500	Colorectal Carcinoma	GDSC	SRTDLEQVP	DEG_APCC_DBOX_1	0.1111
p.H155Q	ACH-000786	Lymphoma	CCLE	SRTDLEQVP	DEG_APCC_DBOX_1	0.7582
p.H155Q	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	SRTDLEQVP	DEG_APCC_DBOX_1	0.7582
p.H155Q	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	SRTDLEQVP	DEG_APCC_DBOX_1	0.7582
p.M155L	EFM-192A	breast	COSMIC	SRTDLEQVP	DEG_APCC_DBOX_1	0.711

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P1Q0	Vacuolar protein sorting-associated protein 54	DEG_APCC_DBOX_1	155:163	SRTDLEQVP	APC,CDC20,FZR1	0.9432	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons