DegronMD - Q9P1W3(TMEM63C)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T764N	TCGA-50-8457	LUAD	TCGA	LNLTPASS	DEG_SCF_FBW7_1	752:759	Mutation rewiring degron network	0.1944
p.T764N	DO218927	LUAD	ICGC	LNLTPASS	DEG_SCF_FBW7_1	752:759	Mutation rewiring degron network	0.1944
p.A761S	TCGA-A5-A0G1	UCEC	TCGA	LNLTPASS	DEG_SCF_FBW7_1	752:759	Mutation rewiring degron network	0.2778
p.A761S	DO42472	UCEC	ICGC	LNLTPASS	DEG_SCF_FBW7_1	752:759	Mutation rewiring degron network	0.2778
p.S735F	TCGA-AP-A051	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	730:734	Mutation rewiring degron network	0.3056
p.S735F	TCGA-W3-AA1Q	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	730:734	Mutation rewiring degron network	0.3056
p.S735F	DO219487	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	730:734	Mutation rewiring degron network	0.3056
p.S735F	DO42673	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	730:734	Mutation rewiring degron network	0.3056
p.A757T	TCGA-AX-A2HC	UCEC	TCGA	LNLTPASS	DEG_SCF_FBW7_1	752:759	Mutation altering degron motif	0.6028
p.A757T	DO218550	BTCA	ICGC	LNLTPASS	DEG_SCF_FBW7_1	752:759	Mutation altering degron motif	0.6028
p.A757T	DO41572	UCEC	ICGC	LNLTPASS	DEG_SCF_FBW7_1	752:759	Mutation altering degron motif	0.6028
p.S758C	TCGA-B8-A54H	KIRC	TCGA	LNLTPASS	DEG_SCF_FBW7_1	752:759	Mutation altering degron motif	0.643
p.S758C	DO49733	KIRC	ICGC	LNLTPASS	DEG_SCF_FBW7_1	752:759	Mutation altering degron motif	0.643
p.E729K	TCGA-ER-A19F	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	730:734	Mutation rewiring degron network	0.3056
p.E729K	DO37679	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	730:734	Mutation rewiring degron network	0.3056
p.V746L	DO228978	LICA	ICGC	LNLTPASS	DEG_SCF_FBW7_1	752:759	Mutation rewiring degron network	0.1667
p.E751K	DO219878	SKCA	ICGC	LNLTPASS	DEG_SCF_FBW7_1	752:759	Mutation rewiring degron network	0.3056
p.S759F	DO229446	SKCA	ICGC	LNLTPASS	DEG_SCF_FBW7_1	752:759	Mutation altering degron motif	0.7982
p.R762K	SIDM00422	Hodgkin's Lymphoma	GDSC	LNLTPASS	DEG_SCF_FBW7_1	752:759	Mutation rewiring degron network	0.25
p.R762K	ACH-001203	Lymphoma	CCLE	LNLTPASS	DEG_SCF_FBW7_1	752:759	Mutation rewiring degron network	0.25
p.R762K	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	LNLTPASS	DEG_SCF_FBW7_1	752:759	Mutation rewiring degron network	0.25
p.M728I	SIDM00955	Melanoma	GDSC	PSSTS	DEG_SPOP_SBC_1	730:734	Mutation rewiring degron network	0.2778
p.M728I	ACH-000812	Skin Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	730:734	Mutation rewiring degron network	0.2778
p.M728I	COLO-783	skin	COSMIC	PSSTS	DEG_SPOP_SBC_1	730:734	Mutation rewiring degron network	0.2778
p.P730L	SIDM00545	Melanoma	GDSC	PSSTS	DEG_SPOP_SBC_1	730:734	Mutation altering degron motif	0.7582
p.P730L	ACH-000987	Skin Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	730:734	Mutation altering degron motif	0.7582
p.P730L	Mewo	skin	COSMIC	PSSTS	DEG_SPOP_SBC_1	730:734	Mutation altering degron motif	0.7582
p.T745N	SIDM01608	Endometrial Carcinoma	GDSC	LNLTPASS	DEG_SCF_FBW7_1	752:759	Mutation rewiring degron network	0.1389
p.T745N	ACH-000990	Endometrial/Uterine Cancer	CCLE	LNLTPASS	DEG_SCF_FBW7_1	752:759	Mutation rewiring degron network	0.1389

Kaplan plot for TMEM63C in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM63C

UniProt ID: Q9P1W3

Entrez ID: 57156

Protein name: Calcium permeable stress-gated cation channel 1 (Transmembrane protein 63C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM63C in