DegronMD

Uniprot ID: Q9P1W3

Source protein: Calcium permeable stress-gated cation channel 1

Source gene: TMEM63C

Class: DEG_SCF_FBW7_1

Location: 752:759

E3 ligase: FBXW7

DEGRON score: 0.8098

ASA_SCORE: 83.125

COIL: 0.8668

CONS_SCORE: 0.3605

DSS_SCORE: 0.6066

HELIX: 0.1141

FCONS_SCORE: 0.9757

RIG_SCORE: 0.6683

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T764N	TCGA-50-8457	LUAD	TCGA	LNLTPASS	DEG_SCF_FBW7_1	0.1944
p.T764N	DO218927	LUAD	ICGC	LNLTPASS	DEG_SCF_FBW7_1	0.1944
p.A761S	TCGA-A5-A0G1	UCEC	TCGA	LNLTPASS	DEG_SCF_FBW7_1	0.2778
p.A761S	DO42472	UCEC	ICGC	LNLTPASS	DEG_SCF_FBW7_1	0.2778
p.A757T	TCGA-AX-A2HC	UCEC	TCGA	LNLTPASS	DEG_SCF_FBW7_1	0.6028
p.A757T	DO218550	BTCA	ICGC	LNLTPASS	DEG_SCF_FBW7_1	0.6028
p.A757T	DO41572	UCEC	ICGC	LNLTPASS	DEG_SCF_FBW7_1	0.6028
p.S758C	TCGA-B8-A54H	KIRC	TCGA	LNLTPASS	DEG_SCF_FBW7_1	0.643
p.S758C	DO49733	KIRC	ICGC	LNLTPASS	DEG_SCF_FBW7_1	0.643
p.V746L	DO228978	LICA	ICGC	LNLTPASS	DEG_SCF_FBW7_1	0.1667
p.E751K	DO219878	SKCA	ICGC	LNLTPASS	DEG_SCF_FBW7_1	0.3056
p.S759F	DO229446	SKCA	ICGC	LNLTPASS	DEG_SCF_FBW7_1	0.7982
p.R762K	SIDM00422	Hodgkin's Lymphoma	GDSC	LNLTPASS	DEG_SCF_FBW7_1	0.25
p.R762K	ACH-001203	Lymphoma	CCLE	LNLTPASS	DEG_SCF_FBW7_1	0.25
p.R762K	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	LNLTPASS	DEG_SCF_FBW7_1	0.25
p.T745N	SIDM01608	Endometrial Carcinoma	GDSC	LNLTPASS	DEG_SCF_FBW7_1	0.1389
p.T745N	ACH-000990	Endometrial/Uterine Cancer	CCLE	LNLTPASS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P1W3	Calcium permeable stress-gated cation channel 1	DEG_SCF_FBW7_1	752:759	LNLTPASS	FBXW7	0.8098	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons