DegronMD - Q9P1Z3(HCN3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S40F	TCGA-B5-A3FC	UCEC	TCGA	KRRHLGTLL	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.1944
p.S40F	DO41871	UCEC	ICGC	KRRHLGTLL	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.1944
p.R63G	TCGA-FD-A62P	BLCA	TCGA	KRRHLGTLL	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.0556
p.R63G	DO44054	BLCA	ICGC	KRRHLGTLL	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.0556
p.R63W	TCGA-FD-A6TC	BLCA	TCGA	KRRHLGTLL	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.0556
p.R63W	TCGA-G2-A2ES	BLCA	TCGA	KRRHLGTLL	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.0556
p.R63W	TCGA-LN-A4A8	ESCA	TCGA	KRRHLGTLL	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.0556
p.R63W	DO49755	BLCA	ICGC	KRRHLGTLL	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.0556
p.R63W	DO785	BLCA	ICGC	KRRHLGTLL	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.0556
p.R63W	ACH-000854	Myeloma	CCLE	KRRHLGTLL	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.0556
p.R46K	SIDM00570	Gastric Carcinoma	GDSC	KRRHLGTLL	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.7237
p.R46K	SIDM00377	Other Sarcomas	GDSC	KRRHLGTLL	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.7237
p.R46K	SIDM01608	Endometrial Carcinoma	GDSC	KRRHLGTLL	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.7237
p.R46K	SIDM01347	Ovarian Carcinoma	GDSC	KRRHLGTLL	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.7237
p.K39N	ACH-001484	Leukemia	CCLE	KRRHLGTLL	DEG_APCC_DBOX_1	45:53	Mutation substituting flanking lysine	0.2778
p.K39N	ACH-001485	Leukemia	CCLE	KRRHLGTLL	DEG_APCC_DBOX_1	45:53	Mutation substituting flanking lysine	0.2778
p.P36T	ACH-001853	Bile Duct Cancer	CCLE	KRRHLGTLL	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.0833

Kaplan plot for HCN3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HCN3

UniProt ID: Q9P1Z3

Entrez ID: 57657

Protein name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HCN3 in