DegronMD

Uniprot ID: Q9P1Z3

Source protein: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

Source gene: HCN3

Class: DEG_APCC_DBOX_1

Location: 45:53

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8995

ASA_SCORE: 67.8222

COIL: 0.2598

CONS_SCORE: 0.4304

DSS_SCORE: 0.6232

HELIX: 0.7203

FCONS_SCORE: 1.031

RIG_SCORE: 0.7036

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S40F	TCGA-B5-A3FC	UCEC	TCGA	KRRHLGTLL	DEG_APCC_DBOX_1	0.1944
p.S40F	DO41871	UCEC	ICGC	KRRHLGTLL	DEG_APCC_DBOX_1	0.1944
p.R63G	TCGA-FD-A62P	BLCA	TCGA	KRRHLGTLL	DEG_APCC_DBOX_1	0.0556
p.R63G	DO44054	BLCA	ICGC	KRRHLGTLL	DEG_APCC_DBOX_1	0.0556
p.R63W	TCGA-FD-A6TC	BLCA	TCGA	KRRHLGTLL	DEG_APCC_DBOX_1	0.0556
p.R63W	TCGA-G2-A2ES	BLCA	TCGA	KRRHLGTLL	DEG_APCC_DBOX_1	0.0556
p.R63W	TCGA-LN-A4A8	ESCA	TCGA	KRRHLGTLL	DEG_APCC_DBOX_1	0.0556
p.R63W	DO49755	BLCA	ICGC	KRRHLGTLL	DEG_APCC_DBOX_1	0.0556
p.R63W	DO785	BLCA	ICGC	KRRHLGTLL	DEG_APCC_DBOX_1	0.0556
p.R63W	ACH-000854	Myeloma	CCLE	KRRHLGTLL	DEG_APCC_DBOX_1	0.0556
p.R46K	SIDM00570	Gastric Carcinoma	GDSC	KRRHLGTLL	DEG_APCC_DBOX_1	0.7237
p.R46K	SIDM00377	Other Sarcomas	GDSC	KRRHLGTLL	DEG_APCC_DBOX_1	0.7237
p.R46K	SIDM01608	Endometrial Carcinoma	GDSC	KRRHLGTLL	DEG_APCC_DBOX_1	0.7237
p.R46K	SIDM01347	Ovarian Carcinoma	GDSC	KRRHLGTLL	DEG_APCC_DBOX_1	0.7237
p.K39N	ACH-001484	Leukemia	CCLE	KRRHLGTLL	DEG_APCC_DBOX_1	0.2778
p.K39N	ACH-001485	Leukemia	CCLE	KRRHLGTLL	DEG_APCC_DBOX_1	0.2778
p.P36T	ACH-001853	Bile Duct Cancer	CCLE	KRRHLGTLL	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P1Z3	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3	DEG_APCC_DBOX_1	45:53	KRRHLGTLL	APC,CDC20,FZR1	0.8995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons