DegronMD - Q9P232(CNTN3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A698T	TCGA-A5-A0G1	UCEC	TCGA	TEEAVPEV	DEG_COP1_1	695:702	Mutation altering degron motif	0.6028
p.A698T	DO42472	UCEC	ICGC	TEEAVPEV	DEG_COP1_1	695:702	Mutation altering degron motif	0.6028
p.E696G	TCGA-BT-A2LB	BLCA	TCGA	TEEAVPEV	DEG_COP1_1	695:702	Mutation altering degron motif	0.7199
p.E696G	DO44098	BLCA	ICGC	TEEAVPEV	DEG_COP1_1	695:702	Mutation altering degron motif	0.7199
p.P686Q	TCGA-BT-A2LB	BLCA	TCGA	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.0833
p.P686Q	DO44098	BLCA	ICGC	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.0833
p.V693E	TCGA-CV-A6JU	HNSC	TCGA	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.2778
p.V693E	DO52073	HNSC	ICGC	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.2778
p.E701K	TCGA-D1-A15X	UCEC	TCGA	TEEAVPEV	DEG_COP1_1	695:702	Mutation altering degron motif	0.7022
p.E701K	DO43274	UCEC	ICGC	TEEAVPEV	DEG_COP1_1	695:702	Mutation altering degron motif	0.7022
p.G709E	TCGA-DA-A1HV	SKCM	TCGA	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.1389
p.G709E	DO37659	SKCM	ICGC	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.1389
p.G710R	TCGA-UF-A71A	HNSC	TCGA	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.1111
p.G710R	DO52106	HNSC	ICGC	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.1111
p.P686L	TCGA-W3-AA1R	SKCM	TCGA	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.0833
p.P686L	DO51275	SKCM	ICGC	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.0833
p.E706K	TCGA-YG-AA3N	SKCM	TCGA	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.2222
p.E706K	DO51298	SKCM	ICGC	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.2222
p.G712R	DO223546	CLLE	ICGC	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.0556
p.N708S	DO230334	COCA	ICGC	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.1667
p.N708S	DO229003	COCA	ICGC	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.1667
p.N708S	DO230659	LAML	ICGC	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.1667
p.N708S	DO231140	LAML	ICGC	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.1667
p.S687R	DO233779	GACA	ICGC	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.1111
p.P686T	DO229018	LICA	ICGC	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.0833
p.P686T	SIDM00839	Colorectal Carcinoma	GDSC	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.0833
p.P686T	ACH-000950	Colon/Colorectal Cancer	CCLE	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.0833
p.P686T	LoVo	large intestine	COSMIC	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.0833
p.P703S	DO229218	THCA	ICGC	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.3056
p.S687I	DO229542	UTCA	ICGC	TEEAVPEV	DEG_COP1_1	695:702	Mutation rewiring degron network	0.1111
p.E701D	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	TEEAVPEV	DEG_COP1_1	695:702	Mutation altering degron motif	0.5647
p.E701D	NCI-H2126	lung	COSMIC	TEEAVPEV	DEG_COP1_1	695:702	Mutation altering degron motif	0.5647

Kaplan plot for CNTN3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CNTN3

UniProt ID: Q9P232

Entrez ID: 5067

Protein name: Contactin-3 (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CNTN3 in