DegronMD

Uniprot ID: Q9P232

Source protein: Contactin-3

Source gene: CNTN3

Class: DEG_COP1_1

Location: 695:702

E3 ligase: COP1

DEGRON score: 0.9547

ASA_SCORE: 73.3375

COIL: 0.8936

CONS_SCORE: 0.6548

DSS_SCORE: 0.6347

HELIX: 0.0101

FCONS_SCORE: 0.867

RIG_SCORE: 0.6986

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A698T	TCGA-A5-A0G1	UCEC	TCGA	TEEAVPEV	DEG_COP1_1	0.6028
p.A698T	DO42472	UCEC	ICGC	TEEAVPEV	DEG_COP1_1	0.6028
p.E696G	TCGA-BT-A2LB	BLCA	TCGA	TEEAVPEV	DEG_COP1_1	0.7199
p.E696G	DO44098	BLCA	ICGC	TEEAVPEV	DEG_COP1_1	0.7199
p.P686Q	TCGA-BT-A2LB	BLCA	TCGA	TEEAVPEV	DEG_COP1_1	0.0833
p.P686Q	DO44098	BLCA	ICGC	TEEAVPEV	DEG_COP1_1	0.0833
p.V693E	TCGA-CV-A6JU	HNSC	TCGA	TEEAVPEV	DEG_COP1_1	0.2778
p.V693E	DO52073	HNSC	ICGC	TEEAVPEV	DEG_COP1_1	0.2778
p.E701K	TCGA-D1-A15X	UCEC	TCGA	TEEAVPEV	DEG_COP1_1	0.7022
p.E701K	DO43274	UCEC	ICGC	TEEAVPEV	DEG_COP1_1	0.7022
p.G709E	TCGA-DA-A1HV	SKCM	TCGA	TEEAVPEV	DEG_COP1_1	0.1389
p.G709E	DO37659	SKCM	ICGC	TEEAVPEV	DEG_COP1_1	0.1389
p.G710R	TCGA-UF-A71A	HNSC	TCGA	TEEAVPEV	DEG_COP1_1	0.1111
p.G710R	DO52106	HNSC	ICGC	TEEAVPEV	DEG_COP1_1	0.1111
p.P686L	TCGA-W3-AA1R	SKCM	TCGA	TEEAVPEV	DEG_COP1_1	0.0833
p.P686L	DO51275	SKCM	ICGC	TEEAVPEV	DEG_COP1_1	0.0833
p.E706K	TCGA-YG-AA3N	SKCM	TCGA	TEEAVPEV	DEG_COP1_1	0.2222
p.E706K	DO51298	SKCM	ICGC	TEEAVPEV	DEG_COP1_1	0.2222
p.G712R	DO223546	CLLE	ICGC	TEEAVPEV	DEG_COP1_1	0.0556
p.N708S	DO230334	COCA	ICGC	TEEAVPEV	DEG_COP1_1	0.1667
p.N708S	DO229003	COCA	ICGC	TEEAVPEV	DEG_COP1_1	0.1667
p.N708S	DO230659	LAML	ICGC	TEEAVPEV	DEG_COP1_1	0.1667
p.N708S	DO231140	LAML	ICGC	TEEAVPEV	DEG_COP1_1	0.1667
p.S687R	DO233779	GACA	ICGC	TEEAVPEV	DEG_COP1_1	0.1111
p.P686T	DO229018	LICA	ICGC	TEEAVPEV	DEG_COP1_1	0.0833
p.P686T	SIDM00839	Colorectal Carcinoma	GDSC	TEEAVPEV	DEG_COP1_1	0.0833
p.P686T	ACH-000950	Colon/Colorectal Cancer	CCLE	TEEAVPEV	DEG_COP1_1	0.0833
p.P686T	LoVo	large_intestine	COSMIC	TEEAVPEV	DEG_COP1_1	0.0833
p.P703S	DO229218	THCA	ICGC	TEEAVPEV	DEG_COP1_1	0.3056
p.S687I	DO229542	UTCA	ICGC	TEEAVPEV	DEG_COP1_1	0.1111
p.E701D	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	TEEAVPEV	DEG_COP1_1	0.5647
p.E701D	NCI-H2126	lung	COSMIC	TEEAVPEV	DEG_COP1_1	0.5647

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TEEAVPEV

Degron related mutations and impact score

Drug responses associated with CNTN3 mutations

All proteins holding degron of TEEAVPEV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P232	Contactin-3	DEG_COP1_1	695:702	TEEAVPEV	COP1	0.9547	More...