DegronMD - Q9P283(SEMA5B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S137N	TCGA-A5-A0G2	UCEC	TCGA	ARNYLFRLS	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.1944
p.S137N	DO41235	UCEC	ICGC	ARNYLFRLS	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.1944
p.V132A	TCGA-B5-A11N	UCEC	TCGA	ARNYLFRLS	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.0556
p.V132A	DO41458	UCEC	ICGC	ARNYLFRLS	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.0556
p.A153T	TCGA-BK-A6W3	UCEC	TCGA	ARNYLFRLS	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.25
p.A153T	DO50076	UCEC	ICGC	ARNYLFRLS	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.25
p.T159N	TCGA-D8-A1JN	BRCA	TCGA	ARNYLFRLS	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.0833
p.T159N	DO4311	BRCA	ICGC	ARNYLFRLS	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.0833
p.H134Y	TCGA-FW-A3R5	SKCM	TCGA	ARNYLFRLS	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.1111
p.H134Y	DO37406	SKCM	ICGC	ARNYLFRLS	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.1111
p.P145H	DO228952	LICA	ICGC	ARNYLFRLS	DEG_APCC_DBOX_1	142:150	Mutation altering degron motif	0.7694
p.S138F	DO222415	MELA	ICGC	ARNYLFRLS	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.2222
p.V160M	SIDM02039	Colorectal Carcinoma	GDSC	ARNYLFRLS	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.0556
p.V140A	ACH-000021	Lung Cancer	CCLE	ARNYLFRLS	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.2778
p.V140A	NCI-H1693	lung	COSMIC	ARNYLFRLS	DEG_APCC_DBOX_1	142:150	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons