DegronMD

Uniprot ID: Q9P283

Source protein: Semaphorin-5B

Source gene: SEMA5B

Class: DEG_APCC_DBOX_1

Location: 142:150

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6917

ASA_SCORE: 33.8

COIL: 0.3659

CONS_SCORE: 0.422

DSS_SCORE: 0.0462

HELIX: 0.0017

FCONS_SCORE: 1.2687

RIG_SCORE: 0.9091

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S137N	TCGA-A5-A0G2	UCEC	TCGA	ARNYLFRLS	DEG_APCC_DBOX_1	0.1944
p.S137N	DO41235	UCEC	ICGC	ARNYLFRLS	DEG_APCC_DBOX_1	0.1944
p.V132A	TCGA-B5-A11N	UCEC	TCGA	ARNYLFRLS	DEG_APCC_DBOX_1	0.0556
p.V132A	DO41458	UCEC	ICGC	ARNYLFRLS	DEG_APCC_DBOX_1	0.0556
p.A153T	TCGA-BK-A6W3	UCEC	TCGA	ARNYLFRLS	DEG_APCC_DBOX_1	0.25
p.A153T	DO50076	UCEC	ICGC	ARNYLFRLS	DEG_APCC_DBOX_1	0.25
p.T159N	TCGA-D8-A1JN	BRCA	TCGA	ARNYLFRLS	DEG_APCC_DBOX_1	0.0833
p.T159N	DO4311	BRCA	ICGC	ARNYLFRLS	DEG_APCC_DBOX_1	0.0833
p.H134Y	TCGA-FW-A3R5	SKCM	TCGA	ARNYLFRLS	DEG_APCC_DBOX_1	0.1111
p.H134Y	DO37406	SKCM	ICGC	ARNYLFRLS	DEG_APCC_DBOX_1	0.1111
p.P145H	DO228952	LICA	ICGC	ARNYLFRLS	DEG_APCC_DBOX_1	0.7694
p.S138F	DO222415	MELA	ICGC	ARNYLFRLS	DEG_APCC_DBOX_1	0.2222
p.V160M	SIDM02039	Colorectal Carcinoma	GDSC	ARNYLFRLS	DEG_APCC_DBOX_1	0.0556
p.V140A	ACH-000021	Lung Cancer	CCLE	ARNYLFRLS	DEG_APCC_DBOX_1	0.2778
p.V140A	NCI-H1693	lung	COSMIC	ARNYLFRLS	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P283	Semaphorin-5B	DEG_APCC_DBOX_1	142:150	ARNYLFRLS	APC,CDC20,FZR1	0.6917	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons