DegronMD - Q9P2D7(DNAH1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E3605A	TCGA-3N-A9WC	SKCM	TCGA	HREPLPGIW	DEG_APCC_DBOX_1	3607:3615	Mutation rewiring degron network	0.2778
p.E3605A	DO51234	SKCM	ICGC	HREPLPGIW	DEG_APCC_DBOX_1	3607:3615	Mutation rewiring degron network	0.2778
p.P3606S	TCGA-D3-A8GL	SKCM	TCGA	HREPLPGIW	DEG_APCC_DBOX_1	3607:3615	Mutation rewiring degron network	0.3056
p.P3606S	DO50287	SKCM	ICGC	HREPLPGIW	DEG_APCC_DBOX_1	3607:3615	Mutation rewiring degron network	0.3056
p.R3598L	TCGA-EE-A2MQ	SKCM	TCGA	HREPLPGIW	DEG_APCC_DBOX_1	3607:3615	Mutation rewiring degron network	0.0833
p.R3598L	DO37810	SKCM	ICGC	HREPLPGIW	DEG_APCC_DBOX_1	3607:3615	Mutation rewiring degron network	0.0833
p.E3609D	TCGA-EY-A215	UCEC	TCGA	HREPLPGIW	DEG_APCC_DBOX_1	3607:3615	Mutation altering degron motif	0.5647
p.E3609D	DO42665	UCEC	ICGC	HREPLPGIW	DEG_APCC_DBOX_1	3607:3615	Mutation altering degron motif	0.5647
p.R3598Q	DO233235	GACA	ICGC	HREPLPGIW	DEG_APCC_DBOX_1	3607:3615	Mutation rewiring degron network	0.0833
p.R3598Q	SIDM00146	Breast Carcinoma	GDSC	HREPLPGIW	DEG_APCC_DBOX_1	3607:3615	Mutation rewiring degron network	0.0833
p.R3598Q	ACH-000768	Breast Cancer	CCLE	HREPLPGIW	DEG_APCC_DBOX_1	3607:3615	Mutation rewiring degron network	0.0833
p.R3598Q	MDA-MB-231	breast	COSMIC	HREPLPGIW	DEG_APCC_DBOX_1	3607:3615	Mutation rewiring degron network	0.0833
p.R3598W	DO35442	PACA	ICGC	HREPLPGIW	DEG_APCC_DBOX_1	3607:3615	Mutation rewiring degron network	0.0833
p.Q3617H	DO232224	PBCA	ICGC	HREPLPGIW	DEG_APCC_DBOX_1	3607:3615	Mutation rewiring degron network	0.2778
p.I3614S	SIDM01588	Endometrial Carcinoma	GDSC	HREPLPGIW	DEG_APCC_DBOX_1	3607:3615	Mutation altering degron motif	0.7341
p.I3614S	ACH-000993	Endometrial/Uterine Cancer	CCLE	HREPLPGIW	DEG_APCC_DBOX_1	3607:3615	Mutation altering degron motif	0.7341
p.L3625M	ACH-000541	Myeloma	CCLE	HREPLPGIW	DEG_APCC_DBOX_1	3607:3615	Mutation rewiring degron network	0.0556

Kaplan plot for DNAH1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNAH1

UniProt ID: Q9P2D7

Entrez ID: 25981

Protein name: Dynein axonemal heavy chain 1 (Axonemal beta dynein heavy chain 1) (Ciliary dynein heavy chain 1) (Heat shock regulated protein 1) (HSRF-1) (hDHC7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNAH1 in