DegronMD

Uniprot ID: Q9P2D7

Source protein: Dynein axonemal heavy chain 1

Source gene: DNAH1

Class: DEG_APCC_DBOX_1

Location: 3607:3615

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5435

ASA_SCORE: 66.9556

COIL: 0.7122

CONS_SCORE: 0.6054

DSS_SCORE: 0.1401

HELIX: 0.2621

FCONS_SCORE: 1.2587

RIG_SCORE: 0.7864

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E3605A	TCGA-3N-A9WC	SKCM	TCGA	HREPLPGIW	DEG_APCC_DBOX_1	0.2778
p.E3605A	DO51234	SKCM	ICGC	HREPLPGIW	DEG_APCC_DBOX_1	0.2778
p.P3606S	TCGA-D3-A8GL	SKCM	TCGA	HREPLPGIW	DEG_APCC_DBOX_1	0.3056
p.P3606S	DO50287	SKCM	ICGC	HREPLPGIW	DEG_APCC_DBOX_1	0.3056
p.R3598L	TCGA-EE-A2MQ	SKCM	TCGA	HREPLPGIW	DEG_APCC_DBOX_1	0.0833
p.R3598L	DO37810	SKCM	ICGC	HREPLPGIW	DEG_APCC_DBOX_1	0.0833
p.E3609D	TCGA-EY-A215	UCEC	TCGA	HREPLPGIW	DEG_APCC_DBOX_1	0.5647
p.E3609D	DO42665	UCEC	ICGC	HREPLPGIW	DEG_APCC_DBOX_1	0.5647
p.R3598Q	DO233235	GACA	ICGC	HREPLPGIW	DEG_APCC_DBOX_1	0.0833
p.R3598Q	SIDM00146	Breast Carcinoma	GDSC	HREPLPGIW	DEG_APCC_DBOX_1	0.0833
p.R3598Q	ACH-000768	Breast Cancer	CCLE	HREPLPGIW	DEG_APCC_DBOX_1	0.0833
p.R3598Q	MDA-MB-231	breast	COSMIC	HREPLPGIW	DEG_APCC_DBOX_1	0.0833
p.R3598W	DO35442	PACA	ICGC	HREPLPGIW	DEG_APCC_DBOX_1	0.0833
p.Q3617H	DO232224	PBCA	ICGC	HREPLPGIW	DEG_APCC_DBOX_1	0.2778
p.I3614S	SIDM01588	Endometrial Carcinoma	GDSC	HREPLPGIW	DEG_APCC_DBOX_1	0.7341
p.I3614S	ACH-000993	Endometrial/Uterine Cancer	CCLE	HREPLPGIW	DEG_APCC_DBOX_1	0.7341
p.L3625M	ACH-000541	Myeloma	CCLE	HREPLPGIW	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2D7	Dynein axonemal heavy chain 1	DEG_APCC_DBOX_1	3607:3615	HREPLPGIW	APC,CDC20,FZR1	0.5435	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons