DegronMD - Q9P2G3(KLHL14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P100T	TCGA-05-4427	LUAD	TCGA	PGTPSSS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.2222
p.P100T	DO23666	LUAD	ICGC	PGTPSSS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.2222
p.D113Y	TCGA-98-8022	LUSC	TCGA	PGTPSSS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.25
p.D113Y	DO26934	LUSC	ICGC	PGTPSSS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.25
p.G105E	TCGA-EE-A29S	SKCM	TCGA	PGTPSSS	DEG_SCF_FBW7_1	104:110	Mutation altering degron motif	0.6087
p.G105E	DO37936	SKCM	ICGC	PGTPSSS	DEG_SCF_FBW7_1	104:110	Mutation altering degron motif	0.6087
p.P98Q	TCGA-VQ-A91E	STAD	TCGA	PGTPSSS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.1667
p.P98Q	DO233251	GACA	ICGC	PGTPSSS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.1667
p.P98Q	DO233254	GACA	ICGC	PGTPSSS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.1667
p.P98Q	DO51784	STAD	ICGC	PGTPSSS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.1667
p.P98Q	ACH-000985	Colon/Colorectal Cancer	CCLE	PGTPSSS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.1667
p.Q94H	DO52675	MALY	ICGC	PGTPSSS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.0556
p.Q94L	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGTPSSS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.0556
p.Q97P	SIDM00980	Gastric Carcinoma	GDSC	PGTPSSS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.1389
p.Q97P	ACH-000948	Gastric Cancer	CCLE	PGTPSSS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.1389
p.P98L	SIDM01608	Endometrial Carcinoma	GDSC	PGTPSSS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.1667
p.Q96R	SIDM01498	Acute Myeloid Leukemia	GDSC	PGTPSSS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.1111

Kaplan plot for KLHL14 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KLHL14

UniProt ID: Q9P2G3

Entrez ID: 57565

Protein name: Kelch-like protein 14 (Protein interactor of Torsin-1A) (Printor) (Protein interactor of torsinA)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KLHL14 in