DegronMD

Uniprot ID: Q9P2G3

Source protein: Kelch-like protein 14

Source gene: KLHL14

Class: DEG_SCF_FBW7_1

Location: 104:110

E3 ligase: FBXW7

DEGRON score: 0.6941

ASA_SCORE: 60

COIL: 0.9173

CONS_SCORE: 0.3738

DSS_SCORE: 0.9521

HELIX: 0.0337

FCONS_SCORE: 0.9742

RIG_SCORE: 0.4583

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P100T	TCGA-05-4427	LUAD	TCGA	PGTPSSS	DEG_SCF_FBW7_1	0.2222
p.P100T	DO23666	LUAD	ICGC	PGTPSSS	DEG_SCF_FBW7_1	0.2222
p.D113Y	TCGA-98-8022	LUSC	TCGA	PGTPSSS	DEG_SCF_FBW7_1	0.25
p.D113Y	DO26934	LUSC	ICGC	PGTPSSS	DEG_SCF_FBW7_1	0.25
p.G105E	TCGA-EE-A29S	SKCM	TCGA	PGTPSSS	DEG_SCF_FBW7_1	0.6087
p.G105E	DO37936	SKCM	ICGC	PGTPSSS	DEG_SCF_FBW7_1	0.6087
p.P98Q	TCGA-VQ-A91E	STAD	TCGA	PGTPSSS	DEG_SCF_FBW7_1	0.1667
p.P98Q	DO233251	GACA	ICGC	PGTPSSS	DEG_SCF_FBW7_1	0.1667
p.P98Q	DO233254	GACA	ICGC	PGTPSSS	DEG_SCF_FBW7_1	0.1667
p.P98Q	DO51784	STAD	ICGC	PGTPSSS	DEG_SCF_FBW7_1	0.1667
p.P98Q	ACH-000985	Colon/Colorectal Cancer	CCLE	PGTPSSS	DEG_SCF_FBW7_1	0.1667
p.Q94H	DO52675	MALY	ICGC	PGTPSSS	DEG_SCF_FBW7_1	0.0556
p.Q94L	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGTPSSS	DEG_SCF_FBW7_1	0.0556
p.Q97P	SIDM00980	Gastric Carcinoma	GDSC	PGTPSSS	DEG_SCF_FBW7_1	0.1389
p.Q97P	ACH-000948	Gastric Cancer	CCLE	PGTPSSS	DEG_SCF_FBW7_1	0.1389
p.P98L	SIDM01608	Endometrial Carcinoma	GDSC	PGTPSSS	DEG_SCF_FBW7_1	0.1667
p.Q96R	SIDM01498	Acute Myeloid Leukemia	GDSC	PGTPSSS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2G3	Kelch-like protein 14	DEG_SCF_FBW7_1	104:110	PGTPSSS	FBXW7	0.6941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons