DegronMD - Q9P2H5(USP35)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A599T	TCGA-19-5956	GBM	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.1111
p.A599T	TCGA-IB-7651	PAAD	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.1111
p.C606Y	TCGA-28-5216	GBM	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.3056
p.R610H	TCGA-A5-A0G2	UCEC	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation altering degron motif	0.7133
p.R610H	TCGA-AZ-4315	COAD	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation altering degron motif	0.7133
p.A623T	TCGA-AA-3663	COAD	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.1111
p.R616C	TCGA-AA-3947	COAD	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.3056
p.D620G	TCGA-AX-A2HC	UCEC	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.1944
p.R605C	TCGA-AZ-6601	COAD	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.2778
p.R605C	TCGA-OR-A5LA	ACC	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.2778
p.R616H	TCGA-B5-A3FC	UCEC	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.3056
p.R616H	SIDM01314	Colorectal Carcinoma	GDSC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.3056
p.R616H	SIDM01146	Gastric Carcinoma	GDSC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.3056
p.R616H	ACH-000932	Gastric Cancer	CCLE	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.3056
p.R616H	NCI-SNU-1	stomach	COSMIC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.3056
p.I621T	TCGA-BR-8361	STAD	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.1667
p.I621T	TCGA-HU-A4GQ	STAD	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.1667
p.L598V	TCGA-CV-6961	HNSC	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.0833
p.R609H	TCGA-EO-A22U	UCEC	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation altering degron motif	0.7133
p.F599V	DO7810	COAD	ICGC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.1111
p.V603I	DO46657	PAAD	ICGC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.2222
p.F599L	DO51343	PRAD	ICGC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.1111
p.S597T	SIDM00578	Neuroblastoma	GDSC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.0556
p.S597T	SIDM00394	Cervical Carcinoma	GDSC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.0556
p.S597T	SIDM00487	Colorectal Carcinoma	GDSC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.0556
p.S597T	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.0556
p.S597T	SIDM01217	Other Blood Cancers	GDSC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.0556
p.S597T	SIDM01449	Pancreatic Carcinoma	GDSC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.0556
p.S597T	CCK-81	large intestine	COSMIC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.0556
p.S597T	SISO	cervix	COSMIC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.0556
p.S597T	MY-M12	haematopoietic and lymphoid tissue	COSMIC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.0556
p.S597T	TE-9	oesophagus	COSMIC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.0556
p.S597T	NB1	autonomic ganglia	COSMIC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.0556
p.R607C	SIDM00419	Ewing's Sarcoma	GDSC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation altering degron motif	0.719
p.R607C	TC-71	bone	COSMIC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation altering degron motif	0.719
p.R608C	SIDM01071	Small Cell Lung Carcinoma	GDSC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation altering degron motif	0.8301
p.A607D	SW48	large intestine	COSMIC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation altering degron motif	0.7793
p.A602D	EBC-1	lung	COSMIC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.1944
p.E616D	H2804	pleura	COSMIC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.3056
p.A606P	DMS-273	lung	COSMIC	RRRRLGSVM	DEG_APCC_DBOX_1	607:615	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP35

UniProt ID: Q9P2H5

Entrez ID: 57558

Protein name: Ubiquitin carboxyl-terminal hydrolase 35 (EC 3.4.19.12) (Deubiquitinating enzyme 35) (Ubiquitin thioesterase 35) (Ubiquitin-specific-processing protease 35)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP35 in