DegronMD

Uniprot ID: Q9P2H5

Source protein: Ubiquitin carboxyl-terminal hydrolase 35

Source gene: USP35

Class: DEG_APCC_DBOX_1

Location: 607:615

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5133

ASA_SCORE: 101.4222

COIL: 0.8027

CONS_SCORE: 0.3934

DSS_SCORE: 0.5028

HELIX: 0.1049

FCONS_SCORE: 0.9128

RIG_SCORE: 0.6965

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A599T	TCGA-19-5956	GBM	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	0.1111
p.A599T	TCGA-IB-7651	PAAD	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	0.1111
p.C606Y	TCGA-28-5216	GBM	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	0.3056
p.R610H	TCGA-A5-A0G2	UCEC	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	0.7133
p.R610H	TCGA-AZ-4315	COAD	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	0.7133
p.A623T	TCGA-AA-3663	COAD	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	0.1111
p.R616C	TCGA-AA-3947	COAD	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	0.3056
p.D620G	TCGA-AX-A2HC	UCEC	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	0.1944
p.R605C	TCGA-AZ-6601	COAD	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	0.2778
p.R605C	TCGA-OR-A5LA	ACC	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	0.2778
p.R616H	TCGA-B5-A3FC	UCEC	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	0.3056
p.R616H	SIDM01314	Colorectal Carcinoma	GDSC	RRRRLGSVM	DEG_APCC_DBOX_1	0.3056
p.R616H	SIDM01146	Gastric Carcinoma	GDSC	RRRRLGSVM	DEG_APCC_DBOX_1	0.3056
p.R616H	ACH-000932	Gastric Cancer	CCLE	RRRRLGSVM	DEG_APCC_DBOX_1	0.3056
p.R616H	NCI-SNU-1	stomach	COSMIC	RRRRLGSVM	DEG_APCC_DBOX_1	0.3056
p.I621T	TCGA-BR-8361	STAD	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	0.1667
p.I621T	TCGA-HU-A4GQ	STAD	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	0.1667
p.L598V	TCGA-CV-6961	HNSC	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	0.0833
p.R609H	TCGA-EO-A22U	UCEC	TCGA	RRRRLGSVM	DEG_APCC_DBOX_1	0.7133
p.F599V	DO7810	COAD	ICGC	RRRRLGSVM	DEG_APCC_DBOX_1	0.1111
p.V603I	DO46657	PAAD	ICGC	RRRRLGSVM	DEG_APCC_DBOX_1	0.2222
p.F599L	DO51343	PRAD	ICGC	RRRRLGSVM	DEG_APCC_DBOX_1	0.1111
p.S597T	SIDM00578	Neuroblastoma	GDSC	RRRRLGSVM	DEG_APCC_DBOX_1	0.0556
p.S597T	SIDM00394	Cervical Carcinoma	GDSC	RRRRLGSVM	DEG_APCC_DBOX_1	0.0556
p.S597T	SIDM00487	Colorectal Carcinoma	GDSC	RRRRLGSVM	DEG_APCC_DBOX_1	0.0556
p.S597T	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	RRRRLGSVM	DEG_APCC_DBOX_1	0.0556
p.S597T	SIDM01217	Other Blood Cancers	GDSC	RRRRLGSVM	DEG_APCC_DBOX_1	0.0556
p.S597T	SIDM01449	Pancreatic Carcinoma	GDSC	RRRRLGSVM	DEG_APCC_DBOX_1	0.0556
p.S597T	CCK-81	large_intestine	COSMIC	RRRRLGSVM	DEG_APCC_DBOX_1	0.0556
p.S597T	SISO	cervix	COSMIC	RRRRLGSVM	DEG_APCC_DBOX_1	0.0556
p.S597T	MY-M12	haematopoietic_and_lymphoid_tissue	COSMIC	RRRRLGSVM	DEG_APCC_DBOX_1	0.0556
p.S597T	TE-9	oesophagus	COSMIC	RRRRLGSVM	DEG_APCC_DBOX_1	0.0556
p.S597T	NB1	autonomic_ganglia	COSMIC	RRRRLGSVM	DEG_APCC_DBOX_1	0.0556
p.R607C	SIDM00419	Ewing's Sarcoma	GDSC	RRRRLGSVM	DEG_APCC_DBOX_1	0.719
p.R607C	TC-71	bone	COSMIC	RRRRLGSVM	DEG_APCC_DBOX_1	0.719
p.R608C	SIDM01071	Small Cell Lung Carcinoma	GDSC	RRRRLGSVM	DEG_APCC_DBOX_1	0.8301
p.A607D	SW48	large_intestine	COSMIC	RRRRLGSVM	DEG_APCC_DBOX_1	0.7793
p.A602D	EBC-1	lung	COSMIC	RRRRLGSVM	DEG_APCC_DBOX_1	0.1944
p.E616D	H2804	pleura	COSMIC	RRRRLGSVM	DEG_APCC_DBOX_1	0.3056
p.A606P	DMS-273	lung	COSMIC	RRRRLGSVM	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRRRLGSVM

Degron related mutations and impact score

Drug responses associated with USP35 mutations

All proteins holding degron of RRRRLGSVM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2H5	Ubiquitin carboxyl-terminal hydrolase 35	DEG_APCC_DBOX_1	607:615	RRRRLGSVM	APC,CDC20,FZR1	0.5133	More...