DegronMD - Q9P2I0(CPSF2)

CPSF2

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K481N	TCGA-17-Z022	LUAD	TCGA	EDFLVPEL	DEG_COP1_1	483:490	Mutation blocking ubiquitination signal	0.7222
p.F485L	TCGA-AP-A1E0	UCEC	TCGA	EDFLVPEL	DEG_COP1_1	483:490	Mutation altering degron motif	0.587
p.F485L	DO43154	UCEC	ICGC	EDFLVPEL	DEG_COP1_1	483:490	Mutation altering degron motif	0.587
p.E478D	TCGA-B5-A1MR	UCEC	TCGA	EDFLVPEL	DEG_COP1_1	483:490	Mutation rewiring degron network	0.1944
p.E478D	DO41758	UCEC	ICGC	EDFLVPEL	DEG_COP1_1	483:490	Mutation rewiring degron network	0.1944
p.K499T	TCGA-CA-6718	COAD	TCGA	EDFLVPEL	DEG_COP1_1	483:490	Mutation blocking ubiquitination signal	0.5278
p.K499T	DO7801	COAD	ICGC	EDFLVPEL	DEG_COP1_1	483:490	Mutation blocking ubiquitination signal	0.5278
p.W473C	TCGA-DK-A2I2	BLCA	TCGA	EDFLVPEL	DEG_COP1_1	483:490	Mutation rewiring degron network	0.0556
p.W473C	DO708	BLCA	ICGC	EDFLVPEL	DEG_COP1_1	483:490	Mutation rewiring degron network	0.0556
p.E489D	SIDM00280	Gastric Carcinoma	GDSC	EDFLVPEL	DEG_COP1_1	483:490	Mutation altering degron motif	0.5647
p.E489D	SIDM01559	Melanoma	GDSC	EDFLVPEL	DEG_COP1_1	483:490	Mutation altering degron motif	0.5647
p.E489D	ECC10	stomach	COSMIC	EDFLVPEL	DEG_COP1_1	483:490	Mutation altering degron motif	0.5647

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*NOTE: the Kaplan plots were collected from OncoLnc