DegronMD

Uniprot ID: Q9P2I0

Source protein: Cleavage and polyadenylation specificity factor subunit 2

Source gene: CPSF2

Class: DEG_COP1_1

Location: 483:490

E3 ligase: COP1

DEGRON score: 0.6504

ASA_SCORE: 80.175

COIL: 0.5234

CONS_SCORE: 0.3658

DSS_SCORE: 0.5025

HELIX: 0.402

FCONS_SCORE: 0.8464

RIG_SCORE: 0.8171

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K481N	TCGA-17-Z022	LUAD	TCGA	EDFLVPEL	DEG_COP1_1	0.7222
p.F485L	TCGA-AP-A1E0	UCEC	TCGA	EDFLVPEL	DEG_COP1_1	0.587
p.F485L	DO43154	UCEC	ICGC	EDFLVPEL	DEG_COP1_1	0.587
p.E478D	TCGA-B5-A1MR	UCEC	TCGA	EDFLVPEL	DEG_COP1_1	0.1944
p.E478D	DO41758	UCEC	ICGC	EDFLVPEL	DEG_COP1_1	0.1944
p.K499T	TCGA-CA-6718	COAD	TCGA	EDFLVPEL	DEG_COP1_1	0.5278
p.K499T	DO7801	COAD	ICGC	EDFLVPEL	DEG_COP1_1	0.5278
p.W473C	TCGA-DK-A2I2	BLCA	TCGA	EDFLVPEL	DEG_COP1_1	0.0556
p.W473C	DO708	BLCA	ICGC	EDFLVPEL	DEG_COP1_1	0.0556
p.E489D	SIDM00280	Gastric Carcinoma	GDSC	EDFLVPEL	DEG_COP1_1	0.5647
p.E489D	SIDM01559	Melanoma	GDSC	EDFLVPEL	DEG_COP1_1	0.5647
p.E489D	ECC10	stomach	COSMIC	EDFLVPEL	DEG_COP1_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2I0	Cleavage and polyadenylation specificity factor subunit 2	DEG_COP1_1	483:490	EDFLVPEL	COP1	0.6504	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons