DegronMD - Q9P2N2(ARHGAP28)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E101K	TCGA-B5-A0JY	UCEC	TCGA	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.25
p.K118N	TCGA-D6-A4ZB	HNSC	TCGA	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.0833
p.D113Y	TCGA-DK-A6AV	BLCA	TCGA	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.2222
p.A109V	TCGA-F4-6703	COAD	TCGA	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation altering degron motif	0.6936
p.A109V	SIDM00789	Colorectal Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation altering degron motif	0.6936
p.A109V	SIDM00534	Colorectal Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation altering degron motif	0.6936
p.A109V	HCT-15	large intestine	COSMIC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation altering degron motif	0.6936
p.A109V	HT-115	large intestine	COSMIC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation altering degron motif	0.6936
p.P100L	TCGA-G4-6322	COAD	TCGA	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.2222
p.P100L	DO222420	MELA	ICGC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.2222
p.P100L	SIDM00061	Ovarian Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.2222
p.P100L	SIDM00857	Melanoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.2222
p.P100L	SIDM00987	Thyroid Gland Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.2222
p.P100L	SIDM00684	Glioblastoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.2222
p.P100L	SIDM00399	Head and Neck Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.2222
p.P100L	SIDM00477	Esophageal Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.2222
p.P100L	SIDM01165	Pancreatic Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.2222
p.P100L	SIDM00813	Non-Cancerous	GDSC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.2222
p.P100L	SIDM00899	Pancreatic Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.2222
p.P100L	SIDM01114	Non-Cancerous	GDSC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.2222
p.P100L	SIDM00199	Chondrosarcoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.2222
p.P100L	SIDM00792	Small Cell Lung Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.2222
p.P100L	SIDM00730	Small Cell Lung Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.2222
p.P100L	SIDM00685	Glioblastoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.2222
p.P100L	SIDM00534	Colorectal Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.2222
p.S96F	TCGA-GN-A4U5	SKCM	TCGA	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.1111
p.D108Y	DO48575	BLCA	ICGC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation altering degron motif	0.6214
p.I105V	DO228423	BRCA	ICGC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation altering degron motif	0.7076
p.A104V	DO9908	COAD	ICGC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation altering degron motif	0.6936
p.A104V	HCT-15	large intestine	COSMIC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation altering degron motif	0.6936
p.A104V	HT-115	large intestine	COSMIC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation altering degron motif	0.6936
p.P95L	DO8439	COAD	ICGC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.0833
p.D109N	DO234235	ESAD	ICGC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation altering degron motif	0.6932
p.K113R	DO218136	GACA	ICGC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.2222
p.W116L	DO233807	GACA	ICGC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.1389
p.K113N	DO44446	HNSC	ICGC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.2222
p.G95R	DO26469	LUSC	ICGC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.0833
p.P99L	DO222653	MELA	ICGC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.1944
p.A119S	DO232705	PBCA	ICGC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.0556
p.E96K	DO43041	UCEC	ICGC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.1111
p.D112N	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.25
p.D112N	SU-DHL-8	NS	COSMIC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.25
p.H95Y	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.0833
p.H95Y	NCI-H2126	lung	COSMIC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.0833
p.Y101C	PF-382	haematopoietic and lymphoid tissue	COSMIC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.25
p.A106T	CHL-1	skin	COSMIC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation altering degron motif	0.7139
p.P104T	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation altering degron motif	0.7031
p.D94N	SU-DHL-8	NS	COSMIC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.0556
p.A119T	CHL-1	skin	COSMIC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.0556
p.D107N	SU-DHL-8	NS	COSMIC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation altering degron motif	0.6932
p.P117T	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.1111
p.D118E	HDQ-P1	breast	COSMIC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation rewiring degron network	0.0833
p.Q106R	RMG-I	ovary	COSMIC	VTPVDE	DEG_SCF_FBW7_2	104:109	Mutation altering degron motif	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGAP28

UniProt ID: Q9P2N2

Entrez ID:

Protein name: Rho GTPase-activating protein 28 (Rho-type GTPase-activating protein 28)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGAP28 in