DegronMD

Uniprot ID: Q9P2N2

Source protein: Rho GTPase-activating protein 28

Source gene: ARHGAP28

Class: DEG_SCF_FBW7_2

Location: 104:109

E3 ligase: FBXW7

DEGRON score: 0.6664

ASA_SCORE: 88.35

COIL: 0.789

CONS_SCORE: 0.4615

DSS_SCORE: 0.7913

HELIX: 0.1533

FCONS_SCORE: 1.033

RIG_SCORE: 0.7086

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E101K	TCGA-B5-A0JY	UCEC	TCGA	VTPVDE	DEG_SCF_FBW7_2	0.25
p.K118N	TCGA-D6-A4ZB	HNSC	TCGA	VTPVDE	DEG_SCF_FBW7_2	0.0833
p.D113Y	TCGA-DK-A6AV	BLCA	TCGA	VTPVDE	DEG_SCF_FBW7_2	0.2222
p.A109V	TCGA-F4-6703	COAD	TCGA	VTPVDE	DEG_SCF_FBW7_2	0.6936
p.A109V	SIDM00789	Colorectal Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	0.6936
p.A109V	SIDM00534	Colorectal Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	0.6936
p.A109V	HCT-15	large_intestine	COSMIC	VTPVDE	DEG_SCF_FBW7_2	0.6936
p.A109V	HT-115	large_intestine	COSMIC	VTPVDE	DEG_SCF_FBW7_2	0.6936
p.P100L	TCGA-G4-6322	COAD	TCGA	VTPVDE	DEG_SCF_FBW7_2	0.2222
p.P100L	DO222420	MELA	ICGC	VTPVDE	DEG_SCF_FBW7_2	0.2222
p.P100L	SIDM00061	Ovarian Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	0.2222
p.P100L	SIDM00857	Melanoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	0.2222
p.P100L	SIDM00987	Thyroid Gland Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	0.2222
p.P100L	SIDM00684	Glioblastoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	0.2222
p.P100L	SIDM00399	Head and Neck Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	0.2222
p.P100L	SIDM00477	Esophageal Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	0.2222
p.P100L	SIDM01165	Pancreatic Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	0.2222
p.P100L	SIDM00813	Non-Cancerous	GDSC	VTPVDE	DEG_SCF_FBW7_2	0.2222
p.P100L	SIDM00899	Pancreatic Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	0.2222
p.P100L	SIDM01114	Non-Cancerous	GDSC	VTPVDE	DEG_SCF_FBW7_2	0.2222
p.P100L	SIDM00199	Chondrosarcoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	0.2222
p.P100L	SIDM00792	Small Cell Lung Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	0.2222
p.P100L	SIDM00730	Small Cell Lung Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	0.2222
p.P100L	SIDM00685	Glioblastoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	0.2222
p.P100L	SIDM00534	Colorectal Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	0.2222
p.S96F	TCGA-GN-A4U5	SKCM	TCGA	VTPVDE	DEG_SCF_FBW7_2	0.1111
p.D108Y	DO48575	BLCA	ICGC	VTPVDE	DEG_SCF_FBW7_2	0.6214
p.I105V	DO228423	BRCA	ICGC	VTPVDE	DEG_SCF_FBW7_2	0.7076
p.A104V	DO9908	COAD	ICGC	VTPVDE	DEG_SCF_FBW7_2	0.6936
p.A104V	HCT-15	large_intestine	COSMIC	VTPVDE	DEG_SCF_FBW7_2	0.6936
p.A104V	HT-115	large_intestine	COSMIC	VTPVDE	DEG_SCF_FBW7_2	0.6936
p.P95L	DO8439	COAD	ICGC	VTPVDE	DEG_SCF_FBW7_2	0.0833
p.D109N	DO234235	ESAD	ICGC	VTPVDE	DEG_SCF_FBW7_2	0.6932
p.K113R	DO218136	GACA	ICGC	VTPVDE	DEG_SCF_FBW7_2	0.2222
p.W116L	DO233807	GACA	ICGC	VTPVDE	DEG_SCF_FBW7_2	0.1389
p.K113N	DO44446	HNSC	ICGC	VTPVDE	DEG_SCF_FBW7_2	0.2222
p.G95R	DO26469	LUSC	ICGC	VTPVDE	DEG_SCF_FBW7_2	0.0833
p.P99L	DO222653	MELA	ICGC	VTPVDE	DEG_SCF_FBW7_2	0.1944
p.A119S	DO232705	PBCA	ICGC	VTPVDE	DEG_SCF_FBW7_2	0.0556
p.E96K	DO43041	UCEC	ICGC	VTPVDE	DEG_SCF_FBW7_2	0.1111
p.D112N	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	0.25
p.D112N	SU-DHL-8	NS	COSMIC	VTPVDE	DEG_SCF_FBW7_2	0.25
p.H95Y	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	VTPVDE	DEG_SCF_FBW7_2	0.0833
p.H95Y	NCI-H2126	lung	COSMIC	VTPVDE	DEG_SCF_FBW7_2	0.0833
p.Y101C	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	VTPVDE	DEG_SCF_FBW7_2	0.25
p.A106T	CHL-1	skin	COSMIC	VTPVDE	DEG_SCF_FBW7_2	0.7139
p.P104T	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	VTPVDE	DEG_SCF_FBW7_2	0.7031
p.D94N	SU-DHL-8	NS	COSMIC	VTPVDE	DEG_SCF_FBW7_2	0.0556
p.A119T	CHL-1	skin	COSMIC	VTPVDE	DEG_SCF_FBW7_2	0.0556
p.D107N	SU-DHL-8	NS	COSMIC	VTPVDE	DEG_SCF_FBW7_2	0.6932
p.P117T	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	VTPVDE	DEG_SCF_FBW7_2	0.1111
p.D118E	HDQ-P1	breast	COSMIC	VTPVDE	DEG_SCF_FBW7_2	0.0833
p.Q106R	RMG-I	ovary	COSMIC	VTPVDE	DEG_SCF_FBW7_2	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTPVDE

Degron related mutations and impact score

Drug responses associated with ARHGAP28 mutations

All proteins holding degron of VTPVDE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2N2	Rho GTPase-activating protein 28	DEG_SCF_FBW7_2	104:109	VTPVDE	FBXW7	0.6664	More...