DegronMD - Q9P2W7(B3GAT1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R104H	TCGA-06-1806	GBM	TCGA	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.0556
p.R104H	DO48886	GBM	ICGC	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.0556
p.R104H	DO23316	LINC	ICGC	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.0556
p.R104H	ACH-001577	Leukemia	CCLE	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.0556
p.A100T	TCGA-18-3414	LUSC	TCGA	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.1667
p.A100T	DO26629	LUSC	ICGC	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.1667
p.R95H	TCGA-19-5956	GBM	TCGA	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.3056
p.R95H	DO13863	GBM	ICGC	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.3056
p.T82M	TCGA-55-8089	LUAD	TCGA	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.1667
p.T82M	DO23690	LUAD	ICGC	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.1667
p.T103R	TCGA-56-A4BY	LUSC	TCGA	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.0833
p.T103R	DO45457	LUSC	ICGC	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.0833
p.P78L	TCGA-58-8391	LUSC	TCGA	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.0556
p.P78L	DO45440	LUSC	ICGC	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.0556
p.T90M	TCGA-A6-4107	COAD	TCGA	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation altering degron motif	0.7423
p.T90M	DO10566	COAD	ICGC	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation altering degron motif	0.7423
p.P91S	TCGA-AX-A2HG	UCEC	TCGA	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation altering degron motif	0.6752
p.P91S	TCGA-BG-A222	UCEC	TCGA	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation altering degron motif	0.6752
p.P91S	DO42977	UCEC	ICGC	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation altering degron motif	0.6752
p.P91S	DO41337	UCEC	ICGC	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation altering degron motif	0.6752
p.P96L	TCGA-BA-A4IH	HNSC	TCGA	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.2778
p.P96L	DO52029	HNSC	ICGC	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.2778
p.D81N	TCGA-CG-5721	STAD	TCGA	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.1389
p.D81N	DO38192	STAD	ICGC	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.1389
p.D81G	TCGA-DI-A1BU	UCEC	TCGA	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.1389
p.D81G	DO42023	UCEC	ICGC	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.1389
p.W79R	DO50315	ESAD	ICGC	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.0833
p.H87Q	DO229027	LICA	ICGC	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.3056
p.T85S	DO222908	MELA	ICGC	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.25
p.L102M	SIDM00463	T-Lymphoblastic Leukemia	GDSC	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.1111
p.L102M	ACH-000372	Leukemia	CCLE	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.1111
p.L102M	P12-ICHIKAWA	haematopoietic and lymphoid tissue	COSMIC	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.1111
p.R95C	SIDM01064	Hodgkin's Lymphoma	GDSC	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.3056
p.R95C	ACH-000267	Lymphoma	CCLE	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.3056
p.R95C	HDLM-2	haematopoietic and lymphoid tissue	COSMIC	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.3056
p.P96Q	SIDM00150	Colorectal Carcinoma	GDSC	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.2778
p.P96Q	ACH-000969	Colon/Colorectal Cancer	CCLE	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.2778
p.P96Q	KM12	large intestine	COSMIC	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.2778
p.T103M	ACH-000007	Colon/Colorectal Cancer	CCLE	VVTPTYS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.0833

Kaplan plot for B3GAT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

B3GAT1

UniProt ID: Q9P2W7

Entrez ID: 27087

Protein name: Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 1) (Glucuronosyltransferase P) (GlcAT-P) (UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase) (GlcUAT-P)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for B3GAT1 in