DegronMD

Uniprot ID: Q9P2W7

Source protein: Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

Source gene: B3GAT1

Class: DEG_SCF_FBW7_1

Location: 88:94

E3 ligase: FBXW7

DEGRON score: 0.8806

ASA_SCORE: 28.7571

COIL: 0.6676

CONS_SCORE: 0.7431

DSS_SCORE: 0.3252

HELIX: 0.0119

FCONS_SCORE: 1.3241

RIG_SCORE: 0.8091

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R104H	TCGA-06-1806	GBM	TCGA	VVTPTYS	DEG_SCF_FBW7_1	0.0556
p.R104H	DO48886	GBM	ICGC	VVTPTYS	DEG_SCF_FBW7_1	0.0556
p.R104H	DO23316	LINC	ICGC	VVTPTYS	DEG_SCF_FBW7_1	0.0556
p.R104H	ACH-001577	Leukemia	CCLE	VVTPTYS	DEG_SCF_FBW7_1	0.0556
p.A100T	TCGA-18-3414	LUSC	TCGA	VVTPTYS	DEG_SCF_FBW7_1	0.1667
p.A100T	DO26629	LUSC	ICGC	VVTPTYS	DEG_SCF_FBW7_1	0.1667
p.R95H	TCGA-19-5956	GBM	TCGA	VVTPTYS	DEG_SCF_FBW7_1	0.3056
p.R95H	DO13863	GBM	ICGC	VVTPTYS	DEG_SCF_FBW7_1	0.3056
p.T82M	TCGA-55-8089	LUAD	TCGA	VVTPTYS	DEG_SCF_FBW7_1	0.1667
p.T82M	DO23690	LUAD	ICGC	VVTPTYS	DEG_SCF_FBW7_1	0.1667
p.T103R	TCGA-56-A4BY	LUSC	TCGA	VVTPTYS	DEG_SCF_FBW7_1	0.0833
p.T103R	DO45457	LUSC	ICGC	VVTPTYS	DEG_SCF_FBW7_1	0.0833
p.P78L	TCGA-58-8391	LUSC	TCGA	VVTPTYS	DEG_SCF_FBW7_1	0.0556
p.P78L	DO45440	LUSC	ICGC	VVTPTYS	DEG_SCF_FBW7_1	0.0556
p.T90M	TCGA-A6-4107	COAD	TCGA	VVTPTYS	DEG_SCF_FBW7_1	0.7423
p.T90M	DO10566	COAD	ICGC	VVTPTYS	DEG_SCF_FBW7_1	0.7423
p.P91S	TCGA-AX-A2HG	UCEC	TCGA	VVTPTYS	DEG_SCF_FBW7_1	0.6752
p.P91S	TCGA-BG-A222	UCEC	TCGA	VVTPTYS	DEG_SCF_FBW7_1	0.6752
p.P91S	DO42977	UCEC	ICGC	VVTPTYS	DEG_SCF_FBW7_1	0.6752
p.P91S	DO41337	UCEC	ICGC	VVTPTYS	DEG_SCF_FBW7_1	0.6752
p.P96L	TCGA-BA-A4IH	HNSC	TCGA	VVTPTYS	DEG_SCF_FBW7_1	0.2778
p.P96L	DO52029	HNSC	ICGC	VVTPTYS	DEG_SCF_FBW7_1	0.2778
p.D81N	TCGA-CG-5721	STAD	TCGA	VVTPTYS	DEG_SCF_FBW7_1	0.1389
p.D81N	DO38192	STAD	ICGC	VVTPTYS	DEG_SCF_FBW7_1	0.1389
p.D81G	TCGA-DI-A1BU	UCEC	TCGA	VVTPTYS	DEG_SCF_FBW7_1	0.1389
p.D81G	DO42023	UCEC	ICGC	VVTPTYS	DEG_SCF_FBW7_1	0.1389
p.W79R	DO50315	ESAD	ICGC	VVTPTYS	DEG_SCF_FBW7_1	0.0833
p.H87Q	DO229027	LICA	ICGC	VVTPTYS	DEG_SCF_FBW7_1	0.3056
p.T85S	DO222908	MELA	ICGC	VVTPTYS	DEG_SCF_FBW7_1	0.25
p.L102M	SIDM00463	T-Lymphoblastic Leukemia	GDSC	VVTPTYS	DEG_SCF_FBW7_1	0.1111
p.L102M	ACH-000372	Leukemia	CCLE	VVTPTYS	DEG_SCF_FBW7_1	0.1111
p.L102M	P12-ICHIKAWA	haematopoietic_and_lymphoid_tissue	COSMIC	VVTPTYS	DEG_SCF_FBW7_1	0.1111
p.R95C	SIDM01064	Hodgkin's Lymphoma	GDSC	VVTPTYS	DEG_SCF_FBW7_1	0.3056
p.R95C	ACH-000267	Lymphoma	CCLE	VVTPTYS	DEG_SCF_FBW7_1	0.3056
p.R95C	HDLM-2	haematopoietic_and_lymphoid_tissue	COSMIC	VVTPTYS	DEG_SCF_FBW7_1	0.3056
p.P96Q	SIDM00150	Colorectal Carcinoma	GDSC	VVTPTYS	DEG_SCF_FBW7_1	0.2778
p.P96Q	ACH-000969	Colon/Colorectal Cancer	CCLE	VVTPTYS	DEG_SCF_FBW7_1	0.2778
p.P96Q	KM12	large_intestine	COSMIC	VVTPTYS	DEG_SCF_FBW7_1	0.2778
p.T103M	ACH-000007	Colon/Colorectal Cancer	CCLE	VVTPTYS	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVTPTYS

Degron related mutations and impact score

Drug responses associated with B3GAT1 mutations

All proteins holding degron of VVTPTYS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2W7	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1	DEG_SCF_FBW7_1	88:94	VVTPTYS	FBXW7	0.8806	More...