DegronMD - Q9UBB6(NCDN)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P449L	TCGA-B5-A11G	UCEC	TCGA	PTTPGPT	DEG_SCF_FBW7_1	449:455	Mutation altering degron motif	0.6471
p.P449L	DO43514	UCEC	ICGC	PTTPGPT	DEG_SCF_FBW7_1	449:455	Mutation altering degron motif	0.6471
p.R462W	TCGA-B5-A3FC	UCEC	TCGA	PTTPGPT	DEG_SCF_FBW7_1	449:455	Mutation rewiring degron network	0.1389
p.R462W	TCGA-EO-A3AV	UCEC	TCGA	PTTPGPT	DEG_SCF_FBW7_1	449:455	Mutation rewiring degron network	0.1389
p.R462W	DO52412	UCEC	ICGC	PTTPGPT	DEG_SCF_FBW7_1	449:455	Mutation rewiring degron network	0.1389
p.R462W	DO41871	UCEC	ICGC	PTTPGPT	DEG_SCF_FBW7_1	449:455	Mutation rewiring degron network	0.1389
p.A460T	TCGA-D7-A6EZ	STAD	TCGA	PTTPGPT	DEG_SCF_FBW7_1	449:455	Mutation rewiring degron network	0.1944
p.A460T	DO50119	STAD	ICGC	PTTPGPT	DEG_SCF_FBW7_1	449:455	Mutation rewiring degron network	0.1944
p.Q441H	TCGA-FS-A1ZR	SKCM	TCGA	PTTPGPT	DEG_SCF_FBW7_1	449:455	Mutation rewiring degron network	0.1111
p.Q441H	DO37651	SKCM	ICGC	PTTPGPT	DEG_SCF_FBW7_1	449:455	Mutation rewiring degron network	0.1111
p.S448P	TCGA-MH-A856	KIRP	TCGA	PTTPGPT	DEG_SCF_FBW7_1	449:455	Mutation blocking phosphorylation signal	0.75
p.S448P	DO49774	KIRP	ICGC	PTTPGPT	DEG_SCF_FBW7_1	449:455	Mutation blocking phosphorylation signal	0.75
p.A443V	DO233259	GACA	ICGC	PTTPGPT	DEG_SCF_FBW7_1	449:455	Mutation rewiring degron network	0.1667

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons