DegronMD

Uniprot ID: Q9UBB6

Source protein: Neurochondrin

Source gene: NCDN

Class: DEG_SCF_FBW7_1

Location: 449:455

E3 ligase: FBXW7

DEGRON score: 0.8553

ASA_SCORE: 82.5429

COIL: 0.9464

CONS_SCORE: 0.3993

DSS_SCORE: 0.4063

HELIX: 0.0237

FCONS_SCORE: 0.7703

RIG_SCORE: 0.6598

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P449L	TCGA-B5-A11G	UCEC	TCGA	PTTPGPT	DEG_SCF_FBW7_1	0.6471
p.P449L	DO43514	UCEC	ICGC	PTTPGPT	DEG_SCF_FBW7_1	0.6471
p.R462W	TCGA-B5-A3FC	UCEC	TCGA	PTTPGPT	DEG_SCF_FBW7_1	0.1389
p.R462W	TCGA-EO-A3AV	UCEC	TCGA	PTTPGPT	DEG_SCF_FBW7_1	0.1389
p.R462W	DO52412	UCEC	ICGC	PTTPGPT	DEG_SCF_FBW7_1	0.1389
p.R462W	DO41871	UCEC	ICGC	PTTPGPT	DEG_SCF_FBW7_1	0.1389
p.A460T	TCGA-D7-A6EZ	STAD	TCGA	PTTPGPT	DEG_SCF_FBW7_1	0.1944
p.A460T	DO50119	STAD	ICGC	PTTPGPT	DEG_SCF_FBW7_1	0.1944
p.Q441H	TCGA-FS-A1ZR	SKCM	TCGA	PTTPGPT	DEG_SCF_FBW7_1	0.1111
p.Q441H	DO37651	SKCM	ICGC	PTTPGPT	DEG_SCF_FBW7_1	0.1111
p.S448P	TCGA-MH-A856	KIRP	TCGA	PTTPGPT	DEG_SCF_FBW7_1	0.75
p.S448P	DO49774	KIRP	ICGC	PTTPGPT	DEG_SCF_FBW7_1	0.75
p.A443V	DO233259	GACA	ICGC	PTTPGPT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBB6	Neurochondrin	DEG_SCF_FBW7_1	449:455	PTTPGPT	FBXW7	0.8553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons