DegronMD - Q9UBC3(DNMT3B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S214I	TCGA-28-2506	GBM	TCGA	DSGDGDS	DEG_SCF_TRCP1_1	208:214	Mutation altering degron motif	0.7341
p.P203Q	TCGA-GN-A265	SKCM	TCGA	DSGDGDS	DEG_SCF_TRCP1_1	208:214	Mutation rewiring degron network	0.1944
p.M200I	DO228971	LICA	ICGC	DSGDGDS	DEG_SCF_TRCP1_1	208:214	Mutation rewiring degron network	0.1111
p.W221C	DO229015	LICA	ICGC	DSGDGDS	DEG_SCF_TRCP1_1	208:214	Mutation substituting flanking lysine	0.25
p.W218S	DO25189	LUAD	ICGC	DSGDGDS	DEG_SCF_TRCP1_1	208:214	Mutation rewiring degron network	0.2222
p.P198L	DO37819	SKCM	ICGC	DSGDGDS	DEG_SCF_TRCP1_1	208:214	Mutation rewiring degron network	0.0556
p.G198R	SIDM01878	Non-Cancerous	GDSC	DSGDGDS	DEG_SCF_TRCP1_1	208:214	Mutation rewiring degron network	0.0556
p.G198R	SIDM00053	Pancreatic Carcinoma	GDSC	DSGDGDS	DEG_SCF_TRCP1_1	208:214	Mutation rewiring degron network	0.0556
p.G198R	ACH-002360	Non-Cancerous	CCLE	DSGDGDS	DEG_SCF_TRCP1_1	208:214	Mutation rewiring degron network	0.0556
p.E216G	SIDM00656	Burkitt's Lymphoma	GDSC	DSGDGDS	DEG_SCF_TRCP1_1	208:214	Mutation rewiring degron network	0.2778
p.E216G	SIDM00641	Burkitt's Lymphoma	GDSC	DSGDGDS	DEG_SCF_TRCP1_1	208:214	Mutation rewiring degron network	0.2778
p.E216G	ACH-000944	Lymphoma	CCLE	DSGDGDS	DEG_SCF_TRCP1_1	208:214	Mutation rewiring degron network	0.2778
p.E216G	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	DSGDGDS	DEG_SCF_TRCP1_1	208:214	Mutation rewiring degron network	0.2778
p.G220E	SIDM00867	Glioblastoma	GDSC	DSGDGDS	DEG_SCF_TRCP1_1	208:214	Mutation rewiring degron network	0.1667
p.G220E	ACH-000863	Brain Cancer	CCLE	DSGDGDS	DEG_SCF_TRCP1_1	208:214	Mutation rewiring degron network	0.1667
p.G220E	DBTRG-05MG	central nervous system	COSMIC	DSGDGDS	DEG_SCF_TRCP1_1	208:214	Mutation rewiring degron network	0.1667
p.A204T	COLO-792	skin	COSMIC	DSGDGDS	DEG_SCF_TRCP1_1	208:214	Mutation rewiring degron network	0.2222
p.S208N	Jurkat	haematopoietic and lymphoid tissue	COSMIC	DSGDGDS	DEG_SCF_TRCP1_1	208:214	Mutation altering degron motif	0.7069

Kaplan plot for DNMT3B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNMT3B

UniProt ID: Q9UBC3

Entrez ID: 1789

Protein name: DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNMT3B in