DegronMD

Uniprot ID: Q9UBC3

Source protein: DNA

Source gene: DNMT3B

Class: DEG_SCF_TRCP1_1

Location: 208:214

E3 ligase: BTRC

DEGRON score: 0.9578

ASA_SCORE: 77.4714

COIL: 0.8817

CONS_SCORE: 0.3013

DSS_SCORE: 0.7342

HELIX: 0.0616

FCONS_SCORE: 0.9838

RIG_SCORE: 0.599

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S214I	TCGA-28-2506	GBM	TCGA	DSGDGDS	DEG_SCF_TRCP1_1	0.7341
p.P203Q	TCGA-GN-A265	SKCM	TCGA	DSGDGDS	DEG_SCF_TRCP1_1	0.1944
p.M200I	DO228971	LICA	ICGC	DSGDGDS	DEG_SCF_TRCP1_1	0.1111
p.W221C	DO229015	LICA	ICGC	DSGDGDS	DEG_SCF_TRCP1_1	0.25
p.W218S	DO25189	LUAD	ICGC	DSGDGDS	DEG_SCF_TRCP1_1	0.2222
p.P198L	DO37819	SKCM	ICGC	DSGDGDS	DEG_SCF_TRCP1_1	0.0556
p.G198R	SIDM01878	Non-Cancerous	GDSC	DSGDGDS	DEG_SCF_TRCP1_1	0.0556
p.G198R	SIDM00053	Pancreatic Carcinoma	GDSC	DSGDGDS	DEG_SCF_TRCP1_1	0.0556
p.G198R	ACH-002360	Non-Cancerous	CCLE	DSGDGDS	DEG_SCF_TRCP1_1	0.0556
p.E216G	SIDM00656	Burkitt's Lymphoma	GDSC	DSGDGDS	DEG_SCF_TRCP1_1	0.2778
p.E216G	SIDM00641	Burkitt's Lymphoma	GDSC	DSGDGDS	DEG_SCF_TRCP1_1	0.2778
p.E216G	ACH-000944	Lymphoma	CCLE	DSGDGDS	DEG_SCF_TRCP1_1	0.2778
p.E216G	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	DSGDGDS	DEG_SCF_TRCP1_1	0.2778
p.G220E	SIDM00867	Glioblastoma	GDSC	DSGDGDS	DEG_SCF_TRCP1_1	0.1667
p.G220E	ACH-000863	Brain Cancer	CCLE	DSGDGDS	DEG_SCF_TRCP1_1	0.1667
p.G220E	DBTRG-05MG	central_nervous_system	COSMIC	DSGDGDS	DEG_SCF_TRCP1_1	0.1667
p.A204T	COLO-792	skin	COSMIC	DSGDGDS	DEG_SCF_TRCP1_1	0.2222
p.S208N	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	DSGDGDS	DEG_SCF_TRCP1_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBC3	DNA	DEG_SCF_TRCP1_1	208:214	DSGDGDS	BTRC	0.9578	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons