DegronMD - Q9UBC7(GALP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L63I	TCGA-49-AAR9	LUAD	TCGA	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.0556
p.L63I	DO218921	LUAD	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.0556
p.D73N	TCGA-B5-A3FA	UCEC	TCGA	DGLPYSHPP	CBL_PTK	73:81	Mutation altering degron motif	0.5821
p.D73N	DO227609	COCA	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation altering degron motif	0.5821
p.D73N	DO52402	UCEC	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation altering degron motif	0.5821
p.Q82R	TCGA-B5-A3FA	UCEC	TCGA	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.3056
p.Q82R	DO52402	UCEC	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.3056
p.K85N	TCGA-CA-6717	COAD	TCGA	DGLPYSHPP	CBL_PTK	73:81	Mutation substituting flanking lysine	0.3333
p.K85N	DO8264	COAD	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation substituting flanking lysine	0.3333
p.P83S	TCGA-EE-A2MJ	SKCM	TCGA	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.2778
p.P83S	DO38099	SKCM	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.2778
p.A71T	TCGA-EE-A3AE	SKCM	TCGA	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.2778
p.A71T	DO37802	SKCM	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.2778
p.H79N	TCGA-ER-A2NH	SKCM	TCGA	DGLPYSHPP	CBL_PTK	73:81	Mutation altering degron motif	0.6312
p.H79N	DO47683	SKCM	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation altering degron motif	0.6312
p.A71D	TCGA-FD-A5BR	BLCA	TCGA	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.2778
p.A71D	DO44041	BLCA	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.2778
p.G74E	TCGA-GN-A8LK	SKCM	TCGA	DGLPYSHPP	CBL_PTK	73:81	Mutation altering degron motif	0.6087
p.G74E	DO218857	SKCA	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation altering degron motif	0.6087
p.G74E	DO51259	SKCM	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation altering degron motif	0.6087
p.I72M	DO228483	BRCA	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.3056
p.I72M	DO229010	COCA	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.3056
p.I72M	DO229013	COCA	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.3056
p.I72M	DO229016	COCA	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.3056
p.I72M	DO229005	COCA	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.3056
p.I72M	DO229473	LAML	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.3056
p.I72M	DO50977	LAML	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.3056
p.I72M	DO229047	LICA	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.3056
p.I72M	DO230527	LUSC	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.3056
p.I72M	DO230990	LUSC	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.3056
p.I72M	DO52365	LUSC	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.3056
p.P76R	DO228474	LICA	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation altering degron motif	0.6401
p.P76R	DO228806	LICA	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation altering degron motif	0.6401
p.L68Q	DO229055	LICA	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.1944
p.H79Q	DO232829	NACA	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation altering degron motif	0.647
p.D67E	DO232838	NACA	ICGC	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.1667
p.V88L	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.1389
p.V88L	ACH-000781	Lung Cancer	CCLE	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.1389
p.V88L	NCI-H2023	lung	COSMIC	DGLPYSHPP	CBL_PTK	73:81	Mutation rewiring degron network	0.1389
p.P81S	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	DGLPYSHPP	CBL_PTK	73:81	Mutation altering degron motif	0.6752
p.P81S	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	DGLPYSHPP	CBL_PTK	73:81	Mutation altering degron motif	0.6752
p.L75F	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	DGLPYSHPP	CBL_PTK	73:81	Mutation altering degron motif	0.587

Kaplan plot for GALP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GALP

UniProt ID: Q9UBC7

Entrez ID: 85569

Protein name: Galanin-like peptide

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GALP in