DegronMD

Uniprot ID: Q9UBC7

Source protein: Galanin-like peptide

Source gene: GALP

Class: CBL_PTK

Location: 73:81

E3 ligase: CBL

DEGRON score: 0.9839

ASA_SCORE: 65.8667

COIL: 0.9161

CONS_SCORE: 0.8723

DSS_SCORE: 0.4445

HELIX: 0.0478

FCONS_SCORE: 1.0423

RIG_SCORE: 0.6719

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L63I	TCGA-49-AAR9	LUAD	TCGA	DGLPYSHPP	CBL_PTK	0.0556
p.L63I	DO218921	LUAD	ICGC	DGLPYSHPP	CBL_PTK	0.0556
p.D73N	TCGA-B5-A3FA	UCEC	TCGA	DGLPYSHPP	CBL_PTK	0.5821
p.D73N	DO227609	COCA	ICGC	DGLPYSHPP	CBL_PTK	0.5821
p.D73N	DO52402	UCEC	ICGC	DGLPYSHPP	CBL_PTK	0.5821
p.Q82R	TCGA-B5-A3FA	UCEC	TCGA	DGLPYSHPP	CBL_PTK	0.3056
p.Q82R	DO52402	UCEC	ICGC	DGLPYSHPP	CBL_PTK	0.3056
p.K85N	TCGA-CA-6717	COAD	TCGA	DGLPYSHPP	CBL_PTK	0.3333
p.K85N	DO8264	COAD	ICGC	DGLPYSHPP	CBL_PTK	0.3333
p.P83S	TCGA-EE-A2MJ	SKCM	TCGA	DGLPYSHPP	CBL_PTK	0.2778
p.P83S	DO38099	SKCM	ICGC	DGLPYSHPP	CBL_PTK	0.2778
p.A71T	TCGA-EE-A3AE	SKCM	TCGA	DGLPYSHPP	CBL_PTK	0.2778
p.A71T	DO37802	SKCM	ICGC	DGLPYSHPP	CBL_PTK	0.2778
p.H79N	TCGA-ER-A2NH	SKCM	TCGA	DGLPYSHPP	CBL_PTK	0.6312
p.H79N	DO47683	SKCM	ICGC	DGLPYSHPP	CBL_PTK	0.6312
p.A71D	TCGA-FD-A5BR	BLCA	TCGA	DGLPYSHPP	CBL_PTK	0.2778
p.A71D	DO44041	BLCA	ICGC	DGLPYSHPP	CBL_PTK	0.2778
p.G74E	TCGA-GN-A8LK	SKCM	TCGA	DGLPYSHPP	CBL_PTK	0.6087
p.G74E	DO218857	SKCA	ICGC	DGLPYSHPP	CBL_PTK	0.6087
p.G74E	DO51259	SKCM	ICGC	DGLPYSHPP	CBL_PTK	0.6087
p.I72M	DO228483	BRCA	ICGC	DGLPYSHPP	CBL_PTK	0.3056
p.I72M	DO229010	COCA	ICGC	DGLPYSHPP	CBL_PTK	0.3056
p.I72M	DO229013	COCA	ICGC	DGLPYSHPP	CBL_PTK	0.3056
p.I72M	DO229016	COCA	ICGC	DGLPYSHPP	CBL_PTK	0.3056
p.I72M	DO229005	COCA	ICGC	DGLPYSHPP	CBL_PTK	0.3056
p.I72M	DO229473	LAML	ICGC	DGLPYSHPP	CBL_PTK	0.3056
p.I72M	DO50977	LAML	ICGC	DGLPYSHPP	CBL_PTK	0.3056
p.I72M	DO229047	LICA	ICGC	DGLPYSHPP	CBL_PTK	0.3056
p.I72M	DO230527	LUSC	ICGC	DGLPYSHPP	CBL_PTK	0.3056
p.I72M	DO230990	LUSC	ICGC	DGLPYSHPP	CBL_PTK	0.3056
p.I72M	DO52365	LUSC	ICGC	DGLPYSHPP	CBL_PTK	0.3056
p.P76R	DO228474	LICA	ICGC	DGLPYSHPP	CBL_PTK	0.6401
p.P76R	DO228806	LICA	ICGC	DGLPYSHPP	CBL_PTK	0.6401
p.L68Q	DO229055	LICA	ICGC	DGLPYSHPP	CBL_PTK	0.1944
p.H79Q	DO232829	NACA	ICGC	DGLPYSHPP	CBL_PTK	0.647
p.D67E	DO232838	NACA	ICGC	DGLPYSHPP	CBL_PTK	0.1667
p.V88L	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	DGLPYSHPP	CBL_PTK	0.1389
p.V88L	ACH-000781	Lung Cancer	CCLE	DGLPYSHPP	CBL_PTK	0.1389
p.V88L	NCI-H2023	lung	COSMIC	DGLPYSHPP	CBL_PTK	0.1389
p.P81S	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	DGLPYSHPP	CBL_PTK	0.6752
p.P81S	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	DGLPYSHPP	CBL_PTK	0.6752
p.L75F	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	DGLPYSHPP	CBL_PTK	0.587

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DGLPYSHPP

Degron related mutations and impact score

Drug responses associated with GALP mutations

All proteins holding degron of DGLPYSHPP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBC7	Galanin-like peptide	CBL_PTK	73:81	DGLPYSHPP	CBL	0.9839	More...