DegronMD - Q9UBF8(PI4KB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F340L	TCGA-4Z-AA7R	BLCA	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation rewiring degron network	0.1944
p.F340L	TCGA-AN-A046	BRCA	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation rewiring degron network	0.1944
p.F340L	TCGA-EE-A29G	SKCM	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation rewiring degron network	0.1944
p.F340L	DO51866	BLCA	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation rewiring degron network	0.1944
p.F340L	DO1285	BRCA	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation rewiring degron network	0.1944
p.F340L	DO47303	SKCM	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation rewiring degron network	0.1944
p.R333Q	TCGA-BR-7851	STAD	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation altering degron motif	0.7329
p.R333Q	TCGA-VQ-A8P2	STAD	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation altering degron motif	0.7329
p.R333Q	DO38711	STAD	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation altering degron motif	0.7329
p.R333Q	DO51761	STAD	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation altering degron motif	0.7329
p.E322K	TCGA-BS-A0UF	UCEC	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation altering degron motif	0.7022
p.E322K	DO41488	UCEC	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation altering degron motif	0.7022
p.S318F	TCGA-D3-A51G	SKCM	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation rewiring degron network	0.2222
p.S318F	DO47700	SKCM	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation rewiring degron network	0.2222
p.D325G	TCGA-FI-A2D5	UCEC	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation altering degron motif	0.7198
p.D325G	DO41331	UCEC	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation altering degron motif	0.7198
p.S323R	TCGA-FS-A1ZJ	SKCM	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation altering degron motif	0.7427
p.S323R	DO37956	SKCM	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation altering degron motif	0.7427
p.I324F	DO218774	GACA	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation altering degron motif	0.7415
p.A335D	DO229022	LICA	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation altering degron motif	0.7793
p.T321S	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation rewiring degron network	0.3056
p.T321S	HCC-366	lung	COSMIC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation rewiring degron network	0.3056
p.L344M	SIDM00789	Colorectal Carcinoma	GDSC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation rewiring degron network	0.0833
p.L344M	HCT-15	large intestine	COSMIC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation rewiring degron network	0.0833
p.S319C	SIDM00937	Oral Cavity Carcinoma	GDSC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation rewiring degron network	0.25
p.S319C	CAL-27	upper aerodigestive tract	COSMIC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation rewiring degron network	0.25
p.V332I	SIDM01608	Endometrial Carcinoma	GDSC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation altering degron motif	0.7076
p.A319T	ACH-000897	Thyroid Cancer	CCLE	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation rewiring degron network	0.25
p.R338W	ACH-000966	Ovarian Cancer	CCLE	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation rewiring degron network	0.25
p.L317M	ACH-000997	Colon/Colorectal Cancer	CCLE	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation rewiring degron network	0.1944
p.L317M	ACH-001061	Colon/Colorectal Cancer	CCLE	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation rewiring degron network	0.1944
p.L317M	HCT-15	large intestine	COSMIC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation rewiring degron network	0.1944
p.L332M	ACH-001091	Colon/Colorectal Cancer	CCLE	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation altering degron motif	0.5999
p.L332M	HCT-15	large intestine	COSMIC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation altering degron motif	0.5999
p.R319P	COR-L303	lung	COSMIC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation rewiring degron network	0.25
p.R319H	OVK-18	ovary	COSMIC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation rewiring degron network	0.25
p.A317T	CW-2	large intestine	COSMIC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	322:335	Mutation rewiring degron network	0.1944

Kaplan plot for PI4KB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PI4KB

UniProt ID: Q9UBF8

Entrez ID: 5298

Protein name: Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) (NPIK) (PI4K92) (PI4KIII)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PI4KB in