DegronMD

Uniprot ID: Q9UBF8

Source protein: Phosphatidylinositol 4-kinase beta

Source gene: PI4KB

Class: DEG_ODPH_VHL_1

Location: 322:335

E3 ligase: VHL

DEGRON score: 0.7419

ASA_SCORE: 37.9286

COIL: 0.1221

CONS_SCORE: 0.4663

DSS_SCORE: 0.2944

HELIX: 0.8564

FCONS_SCORE: 1.3851

RIG_SCORE: 0.7972

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A335D	DO229022	LICA	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7793
p.S323R	TCGA-FS-A1ZJ	SKCM	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7427
p.S323R	DO37956	SKCM	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7427
p.I324F	DO218774	GACA	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7415
p.R333Q	TCGA-BR-7851	STAD	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7329
p.R333Q	TCGA-VQ-A8P2	STAD	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7329
p.R333Q	DO38711	STAD	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7329
p.R333Q	DO51761	STAD	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7329
p.D325G	TCGA-FI-A2D5	UCEC	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7198
p.D325G	DO41331	UCEC	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7198
p.V332I	SIDM01608	Endometrial Carcinoma	GDSC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7076
p.E322K	TCGA-BS-A0UF	UCEC	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7022
p.E322K	DO41488	UCEC	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7022
p.L332M	ACH-001091	Colon/Colorectal Cancer	CCLE	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.5999
p.L332M	HCT-15	large_intestine	COSMIC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.5999
p.T321S	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.3056
p.T321S	HCC-366	lung	COSMIC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.3056
p.S319C	SIDM00937	Oral Cavity Carcinoma	GDSC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.25
p.S319C	CAL-27	upper_aerodigestive_tract	COSMIC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.25
p.A319T	ACH-000897	Thyroid Cancer	CCLE	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.25
p.R338W	ACH-000966	Ovarian Cancer	CCLE	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.25
p.R319P	COR-L303	lung	COSMIC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.25
p.R319H	OVK-18	ovary	COSMIC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.25
p.S318F	TCGA-D3-A51G	SKCM	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.2222
p.S318F	DO47700	SKCM	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.2222

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Drug responses associated with PI4KB mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of LAPEREFIKSLMAI

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBF8	Phosphatidylinositol 4-kinase beta	DEG_ODPH_VHL_1	322:335	LAPEREFIKSLMAI	VHL	0.7419	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPEREFIKSLMAI

Degron related mutations and impact score

Drug responses associated with PI4KB mutations

All proteins holding degron of LAPEREFIKSLMAI