DegronMD

Uniprot ID: Q9UBF8

Source protein: Phosphatidylinositol 4-kinase beta

Source gene: PI4KB

Class: DEG_ODPH_VHL_1

Location: 322:335

E3 ligase: VHL

DEGRON score: 0.7419

ASA_SCORE: 37.9286

COIL: 0.1221

CONS_SCORE: 0.4663

DSS_SCORE: 0.2944

HELIX: 0.8564

FCONS_SCORE: 1.3851

RIG_SCORE: 0.7972

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F340L	TCGA-4Z-AA7R	BLCA	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.1944
p.F340L	TCGA-AN-A046	BRCA	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.1944
p.F340L	TCGA-EE-A29G	SKCM	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.1944
p.F340L	DO51866	BLCA	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.1944
p.F340L	DO1285	BRCA	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.1944
p.F340L	DO47303	SKCM	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.1944
p.R333Q	TCGA-BR-7851	STAD	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7329
p.R333Q	TCGA-VQ-A8P2	STAD	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7329
p.R333Q	DO38711	STAD	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7329
p.R333Q	DO51761	STAD	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7329
p.E322K	TCGA-BS-A0UF	UCEC	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7022
p.E322K	DO41488	UCEC	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7022
p.S318F	TCGA-D3-A51G	SKCM	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.2222
p.S318F	DO47700	SKCM	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.2222
p.D325G	TCGA-FI-A2D5	UCEC	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7198
p.D325G	DO41331	UCEC	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7198
p.S323R	TCGA-FS-A1ZJ	SKCM	TCGA	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7427
p.S323R	DO37956	SKCM	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7427
p.I324F	DO218774	GACA	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7415
p.A335D	DO229022	LICA	ICGC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7793
p.T321S	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.3056
p.T321S	HCC-366	lung	COSMIC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.3056
p.L344M	SIDM00789	Colorectal Carcinoma	GDSC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.0833
p.L344M	HCT-15	large_intestine	COSMIC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.0833
p.S319C	SIDM00937	Oral Cavity Carcinoma	GDSC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.25
p.S319C	CAL-27	upper_aerodigestive_tract	COSMIC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.25
p.V332I	SIDM01608	Endometrial Carcinoma	GDSC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.7076
p.A319T	ACH-000897	Thyroid Cancer	CCLE	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.25
p.R338W	ACH-000966	Ovarian Cancer	CCLE	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.25
p.L317M	ACH-000997	Colon/Colorectal Cancer	CCLE	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.1944
p.L317M	ACH-001061	Colon/Colorectal Cancer	CCLE	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.1944
p.L317M	HCT-15	large_intestine	COSMIC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.1944
p.L332M	ACH-001091	Colon/Colorectal Cancer	CCLE	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.5999
p.L332M	HCT-15	large_intestine	COSMIC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.5999
p.R319P	COR-L303	lung	COSMIC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.25
p.R319H	OVK-18	ovary	COSMIC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.25
p.A317T	CW-2	large_intestine	COSMIC	LAPEREFIKSLMAI	DEG_ODPH_VHL_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPEREFIKSLMAI

Degron related mutations and impact score

Drug responses associated with PI4KB mutations

All proteins holding degron of LAPEREFIKSLMAI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBF8	Phosphatidylinositol 4-kinase beta	DEG_ODPH_VHL_1	322:335	LAPEREFIKSLMAI	VHL	0.7419	More...