DegronMD - Q9UBF9(MYOT)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A137E	TCGA-17-Z053	LUAD	TCGA	IPRTPDHE	DEG_SCF_FBW7_2	142:149	Mutation rewiring degron network	0.1944
p.E148K	DO49797	BLCA	ICGC	IPRTPDHE	DEG_SCF_FBW7_2	142:149	Mutation altering degron motif	0.7022
p.R136C	DO51407	PRAD	ICGC	IPRTPDHE	DEG_SCF_FBW7_2	142:149	Mutation rewiring degron network	0.1667
p.D147G	DO36556	READ	ICGC	IPRTPDHE	DEG_SCF_FBW7_2	142:149	Mutation altering degron motif	0.6087
p.P134T	DO37523	SKCM	ICGC	IPRTPDHE	DEG_SCF_FBW7_2	142:149	Mutation rewiring degron network	0.1111
p.P134Q	DO47578	SKCM	ICGC	IPRTPDHE	DEG_SCF_FBW7_2	142:149	Mutation rewiring degron network	0.1111
p.N143H	DO47769	STAD	ICGC	IPRTPDHE	DEG_SCF_FBW7_2	142:149	Mutation altering degron motif	0.7423
p.F132L	DO41379	UCEC	ICGC	IPRTPDHE	DEG_SCF_FBW7_2	142:149	Mutation substituting flanking lysine	0.1667
p.A139V	SIDM00333	Endometrial Carcinoma	GDSC	IPRTPDHE	DEG_SCF_FBW7_2	142:149	Mutation rewiring degron network	0.25
p.A139V	MFE-319	endometrium	COSMIC	IPRTPDHE	DEG_SCF_FBW7_2	142:149	Mutation rewiring degron network	0.25
p.E149G	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	IPRTPDHE	DEG_SCF_FBW7_2	142:149	Mutation altering degron motif	0.7199
p.E149G	KYSE-150	oesophagus	COSMIC	IPRTPDHE	DEG_SCF_FBW7_2	142:149	Mutation altering degron motif	0.7199
p.M154T	ACH-000751	Leukemia	CCLE	IPRTPDHE	DEG_SCF_FBW7_2	142:149	Mutation substituting flanking lysine	0.3056
p.M154T	ACH-001853	Bile Duct Cancer	CCLE	IPRTPDHE	DEG_SCF_FBW7_2	142:149	Mutation substituting flanking lysine	0.3056
p.M154T	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	IPRTPDHE	DEG_SCF_FBW7_2	142:149	Mutation substituting flanking lysine	0.3056
p.I138T	ACH-000846	Head and Neck Cancer	CCLE	IPRTPDHE	DEG_SCF_FBW7_2	142:149	Mutation rewiring degron network	0.2222
p.I138T	FADU	upper aerodigestive tract	COSMIC	IPRTPDHE	DEG_SCF_FBW7_2	142:149	Mutation rewiring degron network	0.2222

Kaplan plot for MYOT in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYOT

UniProt ID: Q9UBF9

Entrez ID: 9499

Protein name: Myotilin (57 kDa cytoskeletal protein) (Myofibrillar titin-like Ig domains protein) (Titin immunoglobulin domain protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYOT in