DegronMD

Uniprot ID: Q9UBF9

Source protein: Myotilin

Source gene: MYOT

Class: DEG_SCF_FBW7_2

Location: 142:149

E3 ligase: FBXW7

DEGRON score: 0.7375

ASA_SCORE: 87.0125

COIL: 0.7663

CONS_SCORE: 0.5641

DSS_SCORE: 0.7132

HELIX: 0.0634

FCONS_SCORE: 0.8034

RIG_SCORE: 0.6491

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A137E	TCGA-17-Z053	LUAD	TCGA	IPRTPDHE	DEG_SCF_FBW7_2	0.1944
p.E148K	DO49797	BLCA	ICGC	IPRTPDHE	DEG_SCF_FBW7_2	0.7022
p.R136C	DO51407	PRAD	ICGC	IPRTPDHE	DEG_SCF_FBW7_2	0.1667
p.D147G	DO36556	READ	ICGC	IPRTPDHE	DEG_SCF_FBW7_2	0.6087
p.P134T	DO37523	SKCM	ICGC	IPRTPDHE	DEG_SCF_FBW7_2	0.1111
p.P134Q	DO47578	SKCM	ICGC	IPRTPDHE	DEG_SCF_FBW7_2	0.1111
p.N143H	DO47769	STAD	ICGC	IPRTPDHE	DEG_SCF_FBW7_2	0.7423
p.F132L	DO41379	UCEC	ICGC	IPRTPDHE	DEG_SCF_FBW7_2	0.1667
p.A139V	SIDM00333	Endometrial Carcinoma	GDSC	IPRTPDHE	DEG_SCF_FBW7_2	0.25
p.A139V	MFE-319	endometrium	COSMIC	IPRTPDHE	DEG_SCF_FBW7_2	0.25
p.E149G	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	IPRTPDHE	DEG_SCF_FBW7_2	0.7199
p.E149G	KYSE-150	oesophagus	COSMIC	IPRTPDHE	DEG_SCF_FBW7_2	0.7199
p.M154T	ACH-000751	Leukemia	CCLE	IPRTPDHE	DEG_SCF_FBW7_2	0.3056
p.M154T	ACH-001853	Bile Duct Cancer	CCLE	IPRTPDHE	DEG_SCF_FBW7_2	0.3056
p.M154T	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	IPRTPDHE	DEG_SCF_FBW7_2	0.3056
p.I138T	ACH-000846	Head and Neck Cancer	CCLE	IPRTPDHE	DEG_SCF_FBW7_2	0.2222
p.I138T	FADU	upper_aerodigestive_tract	COSMIC	IPRTPDHE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBF9	Myotilin	DEG_SCF_FBW7_2	142:149	IPRTPDHE	FBXW7	0.7375	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons