DegronMD - Q9UBK7(RABL2A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S220L	TCGA-18-3409	LUSC	TCGA	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation altering degron motif	0.6556
p.P226T	TCGA-BF-A1PU	SKCM	TCGA	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation rewiring degron network	0.2222
p.E221D	TCGA-D1-A17Q	UCEC	TCGA	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation altering degron motif	0.5647
p.P226H	TCGA-D3-A2JP	SKCM	TCGA	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation rewiring degron network	0.2222
p.V207M	TCGA-DI-A1NO	UCEC	TCGA	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation rewiring degron network	0.0833
p.E221A	TCGA-EO-A22R	UCEC	TCGA	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation altering degron motif	0.659
p.E206K	DO219896	DLBC	ICGC	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation rewiring degron network	0.0556
p.S221L	DO26444	LUSC	ICGC	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation altering degron motif	0.7667
p.P227H	DO47407	SKCM	ICGC	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation rewiring degron network	0.1944
p.E227K	SIDM01265	Plasma Cell Myeloma	GDSC	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation rewiring degron network	0.1944
p.E227K	SIDM00791	Chronic Myelogenous Leukemia	GDSC	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation rewiring degron network	0.1944
p.E227K	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation rewiring degron network	0.1944
p.E227K	SIDM00673	Breast Carcinoma	GDSC	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation rewiring degron network	0.1944
p.E227K	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation rewiring degron network	0.1944
p.D219A	SIDM00989	Bladder Carcinoma	GDSC	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation altering degron motif	0.7793
p.V223A	ACH-000642	Non-Cancerous	CCLE	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation rewiring degron network	0.3056
p.D209A	ACH-000802	Bladder Cancer	CCLE	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation rewiring degron network	0.1389

Kaplan plot for RABL2A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RABL2A

UniProt ID: Q9UBK7

Entrez ID: 11159

Protein name: Rab-like protein 2A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RABL2A in