DegronMD

Uniprot ID: Q9UBK7

Source protein: Rab-like protein 2A

Source gene: RABL2A

Class: DEG_SCF_FBW7_2

Location: 216:222

E3 ligase: FBXW7

DEGRON score: 0.7392

ASA_SCORE: 107.7286

COIL: 0.8579

CONS_SCORE: 0.246

DSS_SCORE: 0.9063

HELIX: 0.1197

FCONS_SCORE: 1.0316

RIG_SCORE: 0.596

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S220L	TCGA-18-3409	LUSC	TCGA	IETPSEE	DEG_SCF_FBW7_2	0.6556
p.P226T	TCGA-BF-A1PU	SKCM	TCGA	IETPSEE	DEG_SCF_FBW7_2	0.2222
p.E221D	TCGA-D1-A17Q	UCEC	TCGA	IETPSEE	DEG_SCF_FBW7_2	0.5647
p.P226H	TCGA-D3-A2JP	SKCM	TCGA	IETPSEE	DEG_SCF_FBW7_2	0.2222
p.V207M	TCGA-DI-A1NO	UCEC	TCGA	IETPSEE	DEG_SCF_FBW7_2	0.0833
p.E221A	TCGA-EO-A22R	UCEC	TCGA	IETPSEE	DEG_SCF_FBW7_2	0.659
p.E206K	DO219896	DLBC	ICGC	IETPSEE	DEG_SCF_FBW7_2	0.0556
p.S221L	DO26444	LUSC	ICGC	IETPSEE	DEG_SCF_FBW7_2	0.7667
p.P227H	DO47407	SKCM	ICGC	IETPSEE	DEG_SCF_FBW7_2	0.1944
p.E227K	SIDM01265	Plasma Cell Myeloma	GDSC	IETPSEE	DEG_SCF_FBW7_2	0.1944
p.E227K	SIDM00791	Chronic Myelogenous Leukemia	GDSC	IETPSEE	DEG_SCF_FBW7_2	0.1944
p.E227K	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	IETPSEE	DEG_SCF_FBW7_2	0.1944
p.E227K	SIDM00673	Breast Carcinoma	GDSC	IETPSEE	DEG_SCF_FBW7_2	0.1944
p.E227K	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	IETPSEE	DEG_SCF_FBW7_2	0.1944
p.D219A	SIDM00989	Bladder Carcinoma	GDSC	IETPSEE	DEG_SCF_FBW7_2	0.7793
p.V223A	ACH-000642	Non-Cancerous	CCLE	IETPSEE	DEG_SCF_FBW7_2	0.3056
p.D209A	ACH-000802	Bladder Cancer	CCLE	IETPSEE	DEG_SCF_FBW7_2	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons