DegronMD - Q9UNT1(RABL2B)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E227K	TCGA-AX-A2HC	UCEC	TCGA	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation rewiring degron network	0.1944
p.E227K	SIDM00951	T-Lymphoblastic Leukemia	GDSC	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation rewiring degron network	0.1944
p.Q220H	TCGA-BH-A0HK	BRCA	TCGA	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation altering degron motif	0.7582
p.Q212H	TCGA-ER-A195	SKCM	TCGA	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation rewiring degron network	0.2222
p.Q212H	DO47712	SKCM	ICGC	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation rewiring degron network	0.2222
p.E227D	TCGA-FD-A6TG	BLCA	TCGA	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation rewiring degron network	0.1944
p.E217D	DO49760	BLCA	ICGC	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation altering degron motif	0.5647
p.E222Q	DO224732	BRCA	ICGC	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation altering degron motif	0.6744
p.Q210H	DO5717	BRCA	ICGC	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation rewiring degron network	0.1667
p.E217K	DO41572	UCEC	ICGC	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation altering degron motif	0.591
p.P208T	ACH-001653	Gastric Cancer	CCLE	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation rewiring degron network	0.1111
p.P208T	SK-GT-2	stomach	COSMIC	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation rewiring degron network	0.1111
p.P209T	SK-GT-2	stomach	COSMIC	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation rewiring degron network	0.1389
p.P218T	SK-GT-2	stomach	COSMIC	IETPSEE	DEG_SCF_FBW7_2	216:222	Mutation altering degron motif	0.7031

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons