DegronMD

Uniprot ID: Q9UNT1

Source protein: Rab-like protein 2B

Source gene: RABL2B

Class: DEG_SCF_FBW7_2

Location: 216:222

E3 ligase: FBXW7

DEGRON score: 0.7896

ASA_SCORE: 111.4143

COIL: 0.8483

CONS_SCORE: 0.2497

DSS_SCORE: 0.931

HELIX: 0.1297

FCONS_SCORE: 1.0261

RIG_SCORE: 0.5811

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E227K	TCGA-AX-A2HC	UCEC	TCGA	IETPSEE	DEG_SCF_FBW7_2	0.1944
p.E227K	SIDM00951	T-Lymphoblastic Leukemia	GDSC	IETPSEE	DEG_SCF_FBW7_2	0.1944
p.Q220H	TCGA-BH-A0HK	BRCA	TCGA	IETPSEE	DEG_SCF_FBW7_2	0.7582
p.Q212H	TCGA-ER-A195	SKCM	TCGA	IETPSEE	DEG_SCF_FBW7_2	0.2222
p.Q212H	DO47712	SKCM	ICGC	IETPSEE	DEG_SCF_FBW7_2	0.2222
p.E227D	TCGA-FD-A6TG	BLCA	TCGA	IETPSEE	DEG_SCF_FBW7_2	0.1944
p.E217D	DO49760	BLCA	ICGC	IETPSEE	DEG_SCF_FBW7_2	0.5647
p.E222Q	DO224732	BRCA	ICGC	IETPSEE	DEG_SCF_FBW7_2	0.6744
p.Q210H	DO5717	BRCA	ICGC	IETPSEE	DEG_SCF_FBW7_2	0.1667
p.E217K	DO41572	UCEC	ICGC	IETPSEE	DEG_SCF_FBW7_2	0.591
p.P208T	ACH-001653	Gastric Cancer	CCLE	IETPSEE	DEG_SCF_FBW7_2	0.1111
p.P208T	SK-GT-2	stomach	COSMIC	IETPSEE	DEG_SCF_FBW7_2	0.1111
p.P209T	SK-GT-2	stomach	COSMIC	IETPSEE	DEG_SCF_FBW7_2	0.1389
p.P218T	SK-GT-2	stomach	COSMIC	IETPSEE	DEG_SCF_FBW7_2	0.7031

DegronMD: protein-targeted degradation, mutation and drug response to degrons