DegronMD - Q9UBN6(TNFRSF10D)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A323D	TCGA-2W-A8YY	CESC	TCGA	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.1944
p.A323D	DO223732	CESC	ICGC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.1944
p.T345N	DO229041	LICA	ICGC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.0833
p.Q320P	DO229058	LICA	ICGC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.1111
p.E319G	DO229058	LICA	ICGC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.0833
p.R328K	DO222557	MELA	ICGC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation altering degron motif	0.6126
p.R328M	DO35442	PACA	ICGC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation altering degron motif	0.7521
p.E322V	SIDM00683	Prostate Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.1667
p.E322V	ACH-000977	lymph node	CCLE	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.1667
p.E322V	LNCaP-Clone-FGC	prostate	COSMIC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.1667
p.D342E	SIDM00773	Non-Cancerous	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.1667
p.D342E	SIDM00871	Non-Cancerous	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.1667
p.D342E	SIDM00872	Breast Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.1667
p.D342E	SIDM00774	Breast Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.1667
p.D342E	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.1667
p.A341T	SIDM00773	Non-Cancerous	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.1944
p.A341T	SIDM00871	Non-Cancerous	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.1944
p.A341T	SIDM00872	Breast Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.1944
p.A341T	SIDM00774	Breast Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.1944
p.A341T	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.1944
p.S340P	SIDM00773	Non-Cancerous	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.2222
p.S340P	SIDM00871	Non-Cancerous	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.2222
p.S340P	SIDM00872	Breast Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.2222
p.S340P	SIDM00774	Breast Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.2222
p.S340P	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.2222
p.T345P	SIDM00454	Rhabdomyosarcoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.0833
p.T345P	SIDM00846	Cervical Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.0833
p.T345P	SIDM00210	Ovarian Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.0833
p.T345P	SIDM01133	Other Solid Cancers	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	328:336	Mutation rewiring degron network	0.0833

Kaplan plot for TNFRSF10D in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNFRSF10D

UniProt ID: Q9UBN6

Entrez ID: 8793

Protein name: Tumor necrosis factor receptor superfamily member 10D (Decoy receptor 2) (DcR2) (TNF-related apoptosis-inducing ligand receptor 4) (TRAIL receptor 4) (TRAIL-R4) (TRAIL receptor with a truncated death domain) (CD antigen CD264)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TNFRSF10D in