DegronMD

Uniprot ID: Q9UBN6

Source protein: Tumor necrosis factor receptor superfamily member 10D

Source gene: TNFRSF10D

Class: DEG_APCC_DBOX_1

Location: 328:336

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7596

ASA_SCORE: 87.5

COIL: 0.651

CONS_SCORE: 0.5285

DSS_SCORE: 0.3935

HELIX: 0.143

FCONS_SCORE: 0.9854

RIG_SCORE: 0.7934

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A323D	TCGA-2W-A8YY	CESC	TCGA	RRRLLVPVN	DEG_APCC_DBOX_1	0.1944
p.A323D	DO223732	CESC	ICGC	RRRLLVPVN	DEG_APCC_DBOX_1	0.1944
p.T345N	DO229041	LICA	ICGC	RRRLLVPVN	DEG_APCC_DBOX_1	0.0833
p.Q320P	DO229058	LICA	ICGC	RRRLLVPVN	DEG_APCC_DBOX_1	0.1111
p.E319G	DO229058	LICA	ICGC	RRRLLVPVN	DEG_APCC_DBOX_1	0.0833
p.R328K	DO222557	MELA	ICGC	RRRLLVPVN	DEG_APCC_DBOX_1	0.6126
p.R328M	DO35442	PACA	ICGC	RRRLLVPVN	DEG_APCC_DBOX_1	0.7521
p.E322V	SIDM00683	Prostate Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	0.1667
p.E322V	ACH-000977	lymph_node	CCLE	RRRLLVPVN	DEG_APCC_DBOX_1	0.1667
p.E322V	LNCaP-Clone-FGC	prostate	COSMIC	RRRLLVPVN	DEG_APCC_DBOX_1	0.1667
p.D342E	SIDM00773	Non-Cancerous	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	0.1667
p.D342E	SIDM00871	Non-Cancerous	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	0.1667
p.D342E	SIDM00872	Breast Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	0.1667
p.D342E	SIDM00774	Breast Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	0.1667
p.D342E	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	0.1667
p.A341T	SIDM00773	Non-Cancerous	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	0.1944
p.A341T	SIDM00871	Non-Cancerous	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	0.1944
p.A341T	SIDM00872	Breast Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	0.1944
p.A341T	SIDM00774	Breast Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	0.1944
p.A341T	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	0.1944
p.S340P	SIDM00773	Non-Cancerous	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	0.2222
p.S340P	SIDM00871	Non-Cancerous	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	0.2222
p.S340P	SIDM00872	Breast Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	0.2222
p.S340P	SIDM00774	Breast Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	0.2222
p.S340P	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	0.2222
p.T345P	SIDM00454	Rhabdomyosarcoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	0.0833
p.T345P	SIDM00846	Cervical Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	0.0833
p.T345P	SIDM00210	Ovarian Carcinoma	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	0.0833
p.T345P	SIDM01133	Other Solid Cancers	GDSC	RRRLLVPVN	DEG_APCC_DBOX_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRRLLVPVN

Degron related mutations and impact score

Drug responses associated with TNFRSF10D mutations

All proteins holding degron of RRRLLVPVN

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBN6	Tumor necrosis factor receptor superfamily member 10D	DEG_APCC_DBOX_1	328:336	RRRLLVPVN	APC,CDC20,FZR1	0.7596	More...