DegronMD - Q9UDR5(AASS)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R6M	TCGA-EO-A22R	UCEC	TCGA	HRTGLGRLG	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.8632
p.R6M	DO42713	UCEC	ICGC	HRTGLGRLG	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.8632
p.K23N	TCGA-G2-A3VY	BLCA	TCGA	HRTGLGRLG	DEG_APCC_DBOX_1	5:13	Mutation substituting flanking lysine	0.1667
p.K23N	DO590	BLCA	ICGC	HRTGLGRLG	DEG_APCC_DBOX_1	5:13	Mutation substituting flanking lysine	0.1667
p.G19S	DO23272	LINC	ICGC	HRTGLGRLG	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.1667
p.Q3H	SIDM01266	Colorectal Carcinoma	GDSC	HRTGLGRLG	DEG_APCC_DBOX_1	5:13	Mutation substituting flanking lysine	0.3889
p.R6K	SIDM00120	Prostate Carcinoma	GDSC	HRTGLGRLG	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.7237
p.R6K	ACH-000979	Prostate Cancer	CCLE	HRTGLGRLG	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.7237
p.R6K	DU-145	prostate	COSMIC	HRTGLGRLG	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.7237
p.H22N	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	HRTGLGRLG	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.0833
p.H22N	ACH-002240	Lymphoma	CCLE	HRTGLGRLG	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.0833
p.H22N	H9	haematopoietic and lymphoid tissue	COSMIC	HRTGLGRLG	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.0833
p.G10S	SIDM00282	Colorectal Carcinoma	GDSC	HRTGLGRLG	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.5882
p.G10S	ACH-000998	Colon/Colorectal Cancer	CCLE	HRTGLGRLG	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.5882
p.G10S	CW-2	large intestine	COSMIC	HRTGLGRLG	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.5882
p.G13R	SIDM00537	Colorectal Carcinoma	GDSC	HRTGLGRLG	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.6457
p.G13R	SIDM00999	Bladder Carcinoma	GDSC	HRTGLGRLG	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.6457

Kaplan plot for AASS in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AASS

UniProt ID: Q9UDR5

Entrez ID: 10157

Protein name: Alpha-aminoadipic semialdehyde synthase, mitochondrial (LKR/SDH) [Includes: Lysine ketoglutarate reductase (LKR) (LOR) (EC 1.5.1.8); Saccharopine dehydrogenase (SDH) (EC 1.5.1.9)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AASS in