DegronMD

Uniprot ID: Q9UDR5

Source protein: Alpha-aminoadipic semialdehyde synthase, mitochondrial

Source gene: AASS

Class: DEG_APCC_DBOX_1

Location: 5:13

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9779

ASA_SCORE: 76.2111

COIL: 0.673

CONS_SCORE: 0.2275

DSS_SCORE: 0.3628

HELIX: 0.1314

FCONS_SCORE: 1.0547

RIG_SCORE: 0.7484

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R6M	TCGA-EO-A22R	UCEC	TCGA	HRTGLGRLG	DEG_APCC_DBOX_1	0.8632
p.R6M	DO42713	UCEC	ICGC	HRTGLGRLG	DEG_APCC_DBOX_1	0.8632
p.K23N	TCGA-G2-A3VY	BLCA	TCGA	HRTGLGRLG	DEG_APCC_DBOX_1	0.1667
p.K23N	DO590	BLCA	ICGC	HRTGLGRLG	DEG_APCC_DBOX_1	0.1667
p.G19S	DO23272	LINC	ICGC	HRTGLGRLG	DEG_APCC_DBOX_1	0.1667
p.Q3H	SIDM01266	Colorectal Carcinoma	GDSC	HRTGLGRLG	DEG_APCC_DBOX_1	0.3889
p.R6K	SIDM00120	Prostate Carcinoma	GDSC	HRTGLGRLG	DEG_APCC_DBOX_1	0.7237
p.R6K	ACH-000979	Prostate Cancer	CCLE	HRTGLGRLG	DEG_APCC_DBOX_1	0.7237
p.R6K	DU-145	prostate	COSMIC	HRTGLGRLG	DEG_APCC_DBOX_1	0.7237
p.H22N	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	HRTGLGRLG	DEG_APCC_DBOX_1	0.0833
p.H22N	ACH-002240	Lymphoma	CCLE	HRTGLGRLG	DEG_APCC_DBOX_1	0.0833
p.H22N	H9	haematopoietic_and_lymphoid_tissue	COSMIC	HRTGLGRLG	DEG_APCC_DBOX_1	0.0833
p.G10S	SIDM00282	Colorectal Carcinoma	GDSC	HRTGLGRLG	DEG_APCC_DBOX_1	0.5882
p.G10S	ACH-000998	Colon/Colorectal Cancer	CCLE	HRTGLGRLG	DEG_APCC_DBOX_1	0.5882
p.G10S	CW-2	large_intestine	COSMIC	HRTGLGRLG	DEG_APCC_DBOX_1	0.5882
p.G13R	SIDM00537	Colorectal Carcinoma	GDSC	HRTGLGRLG	DEG_APCC_DBOX_1	0.6457
p.G13R	SIDM00999	Bladder Carcinoma	GDSC	HRTGLGRLG	DEG_APCC_DBOX_1	0.6457

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UDR5	Alpha-aminoadipic semialdehyde synthase, mitochondrial	DEG_APCC_DBOX_1	5:13	HRTGLGRLG	APC,CDC20,FZR1	0.9779	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons