DegronMD - Q9UEF7(KL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D103N	TCGA-21-1078	LUSC	TCGA	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	98:111	Mutation altering degron motif	0.5821
p.D103N	DO26653	LUSC	ICGC	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	98:111	Mutation altering degron motif	0.5821
p.L109V	TCGA-CV-7095	HNSC	TCGA	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	98:111	Mutation altering degron motif	0.5654
p.L109V	DO14252	HNSC	ICGC	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	98:111	Mutation altering degron motif	0.5654
p.P97L	TCGA-FW-A3R5	SKCM	TCGA	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	98:111	Mutation rewiring degron network	0.3056
p.P97L	DO37406	SKCM	ICGC	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	98:111	Mutation rewiring degron network	0.3056
p.H95N	TCGA-GN-A263	SKCM	TCGA	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	98:111	Mutation rewiring degron network	0.25
p.H95N	DO37766	SKCM	ICGC	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	98:111	Mutation rewiring degron network	0.25
p.A107T	DO234389	ESAD	ICGC	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	98:111	Mutation altering degron motif	0.6028
p.S115L	DO233884	GACA	ICGC	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	98:111	Mutation rewiring degron network	0.2222
p.A113D	DO229211	THCA	ICGC	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	98:111	Mutation rewiring degron network	0.2778
p.A107V	SIDM00879	Breast Carcinoma	GDSC	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	98:111	Mutation altering degron motif	0.5825
p.A107V	SIDM00930	Osteosarcoma	GDSC	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	98:111	Mutation altering degron motif	0.5825
p.L109P	SIDM00498	Colorectal Carcinoma	GDSC	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	98:111	Mutation altering degron motif	0.7582
p.L109P	SNU-C5	large intestine	COSMIC	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	98:111	Mutation altering degron motif	0.7582

Kaplan plot for KL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KL

UniProt ID: Q9UEF7

Entrez ID: 9365

Protein name: Klotho (EC 3.2.1.31) [Cleaved into: Klotho peptide]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KL in