DegronMD

Uniprot ID: Q9UEF7

Source protein: Klotho

Source gene: KL

Class: DEG_ODPH_VHL_1

Location: 98:111

E3 ligase: VHL

DEGRON score: 0.9647

ASA_SCORE: 64.4929

COIL: 0.8532

CONS_SCORE: 0.2993

DSS_SCORE: 0.6289

HELIX: 0.0799

FCONS_SCORE: 0.7563

RIG_SCORE: 0.6228

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D103N	TCGA-21-1078	LUSC	TCGA	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	0.5821
p.D103N	DO26653	LUSC	ICGC	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	0.5821
p.L109V	TCGA-CV-7095	HNSC	TCGA	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	0.5654
p.L109V	DO14252	HNSC	ICGC	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	0.5654
p.P97L	TCGA-FW-A3R5	SKCM	TCGA	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	0.3056
p.P97L	DO37406	SKCM	ICGC	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	0.3056
p.H95N	TCGA-GN-A263	SKCM	TCGA	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	0.25
p.H95N	DO37766	SKCM	ICGC	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	0.25
p.A107T	DO234389	ESAD	ICGC	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	0.6028
p.S115L	DO233884	GACA	ICGC	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	0.2222
p.A113D	DO229211	THCA	ICGC	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	0.2778
p.A107V	SIDM00879	Breast Carcinoma	GDSC	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	0.5825
p.A107V	SIDM00930	Osteosarcoma	GDSC	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	0.5825
p.L109P	SIDM00498	Colorectal Carcinoma	GDSC	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	0.7582
p.L109P	SNU-C5	large_intestine	COSMIC	LAPPGDSRNASLPL	DEG_ODPH_VHL_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UEF7	Klotho	DEG_ODPH_VHL_1	98:111	LAPPGDSRNASLPL	VHL	0.9647	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons