DegronMD - Q9UEY8(ADD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E77Q	TCGA-55-8208	LUAD	TCGA	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.2778
p.E77Q	DO51192	LUAD	ICGC	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.2778
p.R68W	TCGA-75-5125	LUAD	TCGA	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.8634
p.R68W	TCGA-AX-A2HC	UCEC	TCGA	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.8634
p.R68W	DO24477	LUAD	ICGC	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.8634
p.R68W	DO41572	UCEC	ICGC	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.8634
p.R68W	SIDM01782	Oral Cavity Carcinoma	GDSC	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.8634
p.R68W	ACH-000723	Head and Neck Cancer	CCLE	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.8634
p.Q60E	TCGA-78-8660	LUAD	TCGA	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1389
p.Q60E	DO45321	LUAD	ICGC	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1389
p.R57Q	TCGA-AN-A0AS	BRCA	TCGA	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.0556
p.R57Q	DO5228	BRCA	ICGC	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.0556
p.G82D	TCGA-BR-7851	STAD	TCGA	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1389
p.G82D	DO38711	STAD	ICGC	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1389
p.Q60K	TCGA-ER-A19P	SKCM	TCGA	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1389
p.Q60K	DO47623	SKCM	ICGC	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1389
p.A66V	TCGA-FW-A3R5	SKCM	TCGA	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.3056
p.A66V	DO37406	SKCM	ICGC	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.3056
p.A66V	SIDM00221	Melanoma	GDSC	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.3056
p.H83Y	DO25104	LUAD	ICGC	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1111
p.P85L	SIDM00931	Thyroid Gland Carcinoma	GDSC	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.0556
p.P85L	ACH-000174	Thyroid Cancer	CCLE	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.0556
p.P85L	CAL-62	thyroid	COSMIC	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.0556
p.V58A	ACH-001982	Metastasis	CCLE	FREDLECLI	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.0833

Kaplan plot for ADD3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADD3

UniProt ID: Q9UEY8

Entrez ID: 120

Protein name: Gamma-adducin (Adducin-like protein 70)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADD3 in