DegronMD

Uniprot ID: Q9UEY8

Source protein: Gamma-adducin

Source gene: ADD3

Class: DEG_APCC_DBOX_1

Location: 67:75

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6834

ASA_SCORE: 51.2667

COIL: 0.0196

CONS_SCORE: 0.554

DSS_SCORE: 0.3308

HELIX: 0.979

FCONS_SCORE: 1.2971

RIG_SCORE: 0.8472

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E77Q	TCGA-55-8208	LUAD	TCGA	FREDLECLI	DEG_APCC_DBOX_1	0.2778
p.E77Q	DO51192	LUAD	ICGC	FREDLECLI	DEG_APCC_DBOX_1	0.2778
p.R68W	TCGA-75-5125	LUAD	TCGA	FREDLECLI	DEG_APCC_DBOX_1	0.8634
p.R68W	TCGA-AX-A2HC	UCEC	TCGA	FREDLECLI	DEG_APCC_DBOX_1	0.8634
p.R68W	DO24477	LUAD	ICGC	FREDLECLI	DEG_APCC_DBOX_1	0.8634
p.R68W	DO41572	UCEC	ICGC	FREDLECLI	DEG_APCC_DBOX_1	0.8634
p.R68W	SIDM01782	Oral Cavity Carcinoma	GDSC	FREDLECLI	DEG_APCC_DBOX_1	0.8634
p.R68W	ACH-000723	Head and Neck Cancer	CCLE	FREDLECLI	DEG_APCC_DBOX_1	0.8634
p.Q60E	TCGA-78-8660	LUAD	TCGA	FREDLECLI	DEG_APCC_DBOX_1	0.1389
p.Q60E	DO45321	LUAD	ICGC	FREDLECLI	DEG_APCC_DBOX_1	0.1389
p.R57Q	TCGA-AN-A0AS	BRCA	TCGA	FREDLECLI	DEG_APCC_DBOX_1	0.0556
p.R57Q	DO5228	BRCA	ICGC	FREDLECLI	DEG_APCC_DBOX_1	0.0556
p.G82D	TCGA-BR-7851	STAD	TCGA	FREDLECLI	DEG_APCC_DBOX_1	0.1389
p.G82D	DO38711	STAD	ICGC	FREDLECLI	DEG_APCC_DBOX_1	0.1389
p.Q60K	TCGA-ER-A19P	SKCM	TCGA	FREDLECLI	DEG_APCC_DBOX_1	0.1389
p.Q60K	DO47623	SKCM	ICGC	FREDLECLI	DEG_APCC_DBOX_1	0.1389
p.A66V	TCGA-FW-A3R5	SKCM	TCGA	FREDLECLI	DEG_APCC_DBOX_1	0.3056
p.A66V	DO37406	SKCM	ICGC	FREDLECLI	DEG_APCC_DBOX_1	0.3056
p.A66V	SIDM00221	Melanoma	GDSC	FREDLECLI	DEG_APCC_DBOX_1	0.3056
p.H83Y	DO25104	LUAD	ICGC	FREDLECLI	DEG_APCC_DBOX_1	0.1111
p.P85L	SIDM00931	Thyroid Gland Carcinoma	GDSC	FREDLECLI	DEG_APCC_DBOX_1	0.0556
p.P85L	ACH-000174	Thyroid Cancer	CCLE	FREDLECLI	DEG_APCC_DBOX_1	0.0556
p.P85L	CAL-62	thyroid	COSMIC	FREDLECLI	DEG_APCC_DBOX_1	0.0556
p.V58A	ACH-001982	Metastasis	CCLE	FREDLECLI	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UEY8	Gamma-adducin	DEG_APCC_DBOX_1	67:75	FREDLECLI	APC,CDC20,FZR1	0.6834	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons